drugs for weight loss

Question 1

sympathomimetic amines

Answer 1

benzphtamine
diethylpropion
phendimetrazine
phentermine

Question 2

sympathomimetic amine/antiepileptic combo

Answer 2

phentermine/topiramate ER

Question 3

lipase inhibitor

Answer 3

orlistate (xenical, alli)

Question 4

5HT3R agonist

Answer 4

loraccerin

Question 5

andtidepressant/opioid antagonist combo

Answer 5

bupropion/naltrexone

Question 6

GLP-1 agonist

Answer 6

liraglutide

Question 7

Tx for severe binge eating disorder

Answer 7

lisdexamfetamine

Question 8

phentermine/topiramate ER

Answer 8

phentermine-sympathomimetic amine 
topiramate- epilepsy and migraine drug
schedule IV
if >5% weight loss not achieved in 12wks discontinue slowly
CI in prego
most effective

Question 9

orilstat

Answer 9

available both OTC (alli) an prescription (xenical)
pancreatic and gastric lipase inhibitor 
modestly effective
adverse effects limits use 
CI in prego

Question 10

lorcaserin

Answer 10

selective serotonin 2C agonist suppresses appetite
schedule IV
modestly effective

Question 11

adverse effects of lorcaserin

Answer 11

HA, nausea, dizziness
CI in prego
cannot be combo w/MAOIs, SSRIs, SNRIs

Question 12

bupropion/naltrexone

Answer 12

bupropion-antidepressant/smoking cessation
naltrexone- opioid R antagonist
not controlled substance

Question 13

adverse effects of bupropion/naltrexone

Answer 13

nausea (major reason for discontinuation), HA, constipation, dizziness, dry mouth
CI in prego

Question 14

liraglutide

Answer 14

injectable, GLP-1 agonists used to Tx DMII
black box warning for thyroid C-cell tumors
CI in prego

Question 15

weight loss in DM

Answer 15

orlistat
phentermine/topiramate
lorcaserin
bupropion/naltrexone

Question 16

SSRI

Answer 16

antidepressants may induce weight loss in short term, but weight gain in long term

Question 17

zonisamide

Answer 17

antiepileptic

modest increase in weight loss compared to placebo

Question 18

metformin

Answer 18

modest weight loss

Question 19

adjustable gastric banding

Answer 19

restrictive procedure w/no associated malabsoprtion

Question 20

sleeve gastrectomy

Answer 20

partial gastrectomy

Question 21

roux-en-Y gastric bypass

Answer 21

mixed restrictive and malabsorptive

significant adverse effects

Question 22

lisdexamfetamine

Answer 22

ADHD med

used for binge eating disorde

Question 23

ADRs lisdexamfetamine

Answer 23

dry mouth, insomnia, decreased appetite, constipation, jittery, anxiety