drugs for ADHD

Question 1

stimulants

Answer 1

methyphenidate
dexmethylphenidate
dextroamphetamine
amphetamine mixed salts

Question 2

methyphenidate short acting

Answer 2

ritalin

Question 3

methyphenidate long acting

Answer 3

ritalin LA
concerta
daytrana

Question 4

amphetamine mixed salts short acting

Answer 4

adderal

Question 5

amphetamine mixed slats long actng

Answer 5

adderal XR

Question 6

nonstimulants

Answer 6

atomoxeine

Question 7

Dx of ADHA

Answer 7

6+ symptoms of inattention for >6months to a degree that is maladaptive and inconsistent w/developmental level
or
6+ symptoms of hyperactivity-impulsivity for >6months to a degree that is maladaptive and inconsistent w/developmental level
must present

Question 8

first line for ADHD

Answer 8

methylphenidate

followed by dextroamphetamine and amphetamine mixed salts

Question 9

which transporter does atomoxetine block?

Answer 9

NET

Question 10

which transporter does methyphenidate block?

Answer 10

DAT

Question 11

which transporters does amphetamines block

Answer 11

NET, DAT, SERT

Question 12

methyphenidate (MPH)

Answer 12

active ingredient in majority of stimulate meds
blocks DAT
d-threo enantomer more active

Question 13

IR-MPH

Answer 13

immediate release

can be given as tablets in the am in combo w/long acting formulations or to smooth withdrawal in pm

Question 14

Ritalin-SR

Answer 14

single pulse
up to 8 hours, but variable
usually still prescribed 2x/day

Question 15

ritalin LA

Answer 15

beaded double-pulse biphasic release

Question 16

Concerta/OROS-MPH

Answer 16

osmotic release
12 hrs, less variation
taken once daily

Question 17

daytrana

Answer 17

transdermal patch
ADRs: anorexia, insomina, and tics
2hr delay
w/9hr wear lasts for 11.5hrs

Question 18

dextroamphetamine

Answer 18

some kids unresponsive to MPH may respond and vice-versa
onset w/in 1hr peak 3 hrs, lasts 5hr
2x/day

Question 19

adderall and adderall XR

Answer 19

mixtures of amphetamine salts

adderall XR- biphasic release

Question 20

common ADRs of stimulants

Answer 20

delayed sleep onset
HA
decreased appetite/weight loss
infrequent: emotional lability, either new onset or increase in tics

Question 21

atomoxetine

Answer 21

aka strattera
neither controlled substance nor stimulant
less effective then stimulants
good for kids who cannot loose weight or parents who do not want controlled substance

Question 22

ADRs atomoxetine

Answer 22

somnolence
nausea, vomiting
black box- suicide

Question 23

clonidine and guanfacine

Answer 23

clinically useful for Tx of tics and HTN
in kids to manage sleep problems, aggression, and self injury behavior
less effective then stimulants for ADHD, only Tx hyperactivity and impulsivity, not distractibility
must taper off to prevent HTN crisis

Question 24

bupropion

Answer 24

CI in seizure disorders

Question 25

TCAs

Answer 25

less effective then stimulants for ADHD, only Tx hyperactivity a

Question 26

modafinil

Answer 26

non-stimulant w/mild CV effects | hallucinations and SJS can occur