Drugs for Urinary incontinence: Anti-muscarinics, Sympathomimetics, and Ancillary drugs.

Question 1

What drugs belong to the Anti-muscarinic group?

Answer 1

Oxybutinin
Trospium
Solifenacin
Darifenacin

Question 2

Which antimuscarinics have the shortest T1/2?

Answer 2

oxybutinin (2hr)

Question 3

Which 3 anti-muscarinics have a longer T1/2?

Answer 3

Darifenacin (15hr)
Trospium (20hr)
Solifenacin (60hr)

Question 4

Which anti-muscarinics are metabolized by CYP 2D6?

Answer 4

Darifenacin

Question 5

Which Anti-muscarinics are metabolized by CYP 2A4?

Answer 5

Oxybutinin
Solifenacin
Darifenacin

Question 6

Which anti-muscarinic undergoes mostly renal excretion?

Answer 6

Trospium

Question 7

Which anti-muscarinic must be taken on an empty stomach?

Answer 7

Trospium

Question 8

Which Which anti-muscarinic does not undergo metabolism by CYPs?

Answer 8

Trospium

Question 9

Which antimuscarinic is M3 selective?

Answer 9

Darifenacin

Question 10

What drugs belong to the Sympathomimetic group of drugs for urinary incontinence?

Answer 10

Mirabegron
Pseudo-Ephedrine
Ephedra

Question 11

What is the MOA of Mirabegron?

Answer 11

Beta-3 specific agonist

Question 12

What is the ADME of Mirabegron?

Answer 12

Lowest oral bioavailability

metabolized by CYP3A4&raquo_space; CYP2D6, butylcholinesterase, UGT, and EtOH dehydrogenase

10% renal excretion

Question 13

What adverse effects are associated with Mirabegron?

Answer 13

increased blood pressure (monitor it)

Tachycardia