Drugs for Endometrial Cancer Flashcards
1
Q
What drugs are used in the treatment of Endometrial Cancer?
A
Medroxyprogesterone
Megestrol
2
Q
What is the MOA of Megestrol?
A
Megestrol is a synthetic oral progestin that suppresses pituitary LH and increases estrogen degradation. This promotes differentiation and maintenance of the endometrium.
3
Q
What are the adverse effects associated with Megestrol?
A
Weight gain PM Sx Rash Tumor flare Hypercalcemia Hypercoagulability