Drugs for Schizophrenia

Question 1

Psychotic symptoms of Schizophrenia

Answer 1

Hallucinations
Delusions
Disorganized speech
Disorganized flow of thoughts
Absence of clear, goal-directed behavior

Question 2

Schizophrenia

Answer 2

Thought disorder where patients have difficulty perceiving reality

Example: hearing voices, seeing people, or things that are aren’t there

Question 3

Etiology

Answer 3

The cause of the disease

Question 4

Concordance

Answer 4

If one twin has the disease, what is the likelihood that the other twin will also have the disease

50-80%

Question 5

How is schizophrenia caused by the environment?

Answer 5

Maternal infections and maternal starvation are both associated with an increased risk of the baby developing schizophrenia

Question 6

Chlorpromazine

Answer 6

First antipsychotic drug

Question 7

What are the features of all antipsychotic drugs?

Answer 7

Block D2 dopamine receptors

Question 8

1- Typical antipsychotics

Answer 8

Chlorpromzine

Haloperidol

Blockade of the D2 receptors

Question 9

Adverse effects of typical antipsychotics

Answer 9

Motor Impairment such as Parkinson’s disease

Slow movement and Rigid movement

Causes anhedonia (lack of pleasure)

Alter productive hormones

Prolactin: when women are breastfeeding to promote breast tissue differentiation and milk production are increased

Question 10

2- Atypical antipsychotics

Answer 10

Clozapine and Atypical

Blocks more of the Serotonin receptors

Question 11

Clozapine

Answer 11

Most effective treatment for schizophrenia, but it is rarely given as the first drug because it can cause a fatal loss of white blood cells

Fatal side effect of white blood cell loss

Question 12

Side effects of atypical antipsychotics?

Answer 12

Don’t have the motor side effects

Causes metabolic syndrome (because of weight gain, type 2 diabetes, and heart disease)

Weight gain reduces compliance and increases the risk of co-morbidities