DRUGS FOR RESPIRATORY SYSTEM Flashcards
Blocks cough reflex
ANTITUSSIVES
Decrease blood flow to
the upper respiratory tract and decrease the
over production of secretion
DECONGESTANTS
Block the release or action
of histamine
ANTIHISTAMINES
Increase productive cough
to clear the airway.
EXPECTORANTS
Liquefy respiratory secretion to
aid the clearing of the airways.
MUCOLYTICS
Adverse effects: drying effect on the mucous
membrane, (nausea, constipation), increased
respiratory tract secretion, feelings of
congestion, drowsiness, sedation.
MUCOLYTICS
It is the treatment of non productive
cough
ANTITUSSIVES
MOA: act directly on the medullary cough
center of the brain to depress the cough reflex
ANTITUSSIVES
codeine (generic only)
ANTITUSSIVES
guaifenesin & codeine
ANTITUSSIVES
hydrocodone bitartrate
ANTITUSSIVES
dextromethorphan (Benylin, Robitussin):
does not cause respiratory depression,
neither cause physical dependence nor
tolerance
ANTITUSSIVES
CI: head injury, CNS depression
ANTITUSSIVES
Other Antitussives
MOA: directly act on respiratory tract
ambot basta other antitussives
stimulates secretory cells in the respiratory tract lining = more copious
secretion = buffers the irritation in the
respiratory tract wall that stimulate the
cough
terpin hydrate ( generic only) = OTHER ANTITUSSIVES
acts as a local anesthetic on the respiratory passages, lung, pleura, blocking the effectiveness
of stretch receptors that stimulate cough
reflex
benzonatate (Tessalon) = OTHER ANTITUSSIVES
CI: post op; asthma, emphysema
BASTA OTHER ANTITUSSIVES BUSIT BUSIT
NURSING ACTIONS: Do not take longer than the
recommended
ANTITUSSIVES
NURSING ACTIONS: Further medical evaluation of cough
ANTITUSSIVES
NURSNG ACTIONS: Wait 15- 20 minutes after taking the syrup before drinking any liquid
ANTITUSSIVES
NURSING ACTIONS: Other measures to relieve cough (humidity, cool temperatures, fluids,
topical lozenges)
ANTITUSSIVES
For common colds, sinusitis, allergic
rhinitis, otitis media
DECONGESTANTS
Usually adrenergic or sympathomimetics( local
vasoconstriction = decrease blood flow to the irritated and dilated capillary on the mucous membranes lining the nasal passages and sinus cavities
DECONGESTANTS
Rhinitis medicamentosa = –rebound
congestion that accompany frequent
and prolonged use of these drugs
DECONGESTANTS
Sympathomimetic, immediate onset, less chance of systemic effects, available in nasal spray
TOPICAL NASAL DECONGESTANTS
ephedrine (Kondon’s nasal)
DECONGESTANTS
oxymetazoline (Aftrin)
DECONGESTANTS
phenylephrine(Coricidin)
DECONGESTANTS
tetrahydrozoline (Tyzine)
DECONGESTANTS
xylometazoline (Otrivin)
DECONGESTANTS
CI: lesion or erosion on the mucous
membrane, HPN, DM, thyroid disease,
coronary disease
DECONGESTANTS
AE: local stinging and burning sensation,
rebound congestion ( longer than 3-5 days),sympathomimetic effects ( increased
pulse, BPand urinary retention
DECONGESTANTS
DI:
+ cyclopropane/ halothane anesthesia=serious
cardiovascular effects
+ other sympathomimetics =toxic effects
+ other sympatholytics = noneffective
DECONGESTANTS
Directly block the effect of inflammation
TOPICAL NASAL STEROID DECONGESTANTS
Takes several weeks to be real effective and are more often used in cases of chronic rhinitis and post nasal polyps removal
TOPICAL NASAL STEROID DECONGESTANTS
Beclomethasone, budesonide,
dexamethasone, flunisolide, fluticasone,
triamcinolone
TOPICAL NASAL STEROID DECONGESTANTS
CI: acute infections (candida albicans infections),airborne infection (chicken pox,
measles)pulmonary tuberculosis
TOPICAL NASAL STEROID DECONGESTANTS
AE: same with topical + post nasal surgery or
trauma = monitor closely for it suppresses
healing
TOPICAL NASAL STEROID DECONGESTANTS
Shrink the nasal mucous membrane by stimulating the alpha adrenergic receptors in the nasal mucous membrane
ORAL DECONGESTANT
pseudoephedrine
ORAL DECONGESTANT
CI: conditions exacerbated by sympathetic
activity
ORAL DECONGESTANT
AE: rebound congestion, sympathetic effects (
anxiety, tenseness, restlessness, tremors
arrhythmias, sweating, pallor)
ORAL DECONGESTANT
NURSING ACTIONS:
- Clear nasal passages before using
- Tilt the head back when applying the drops or spray
- Keep it tilted back for a few seconds
after administration
- Not to use more than 5 days (topical), not more than 7 days (PO), not more than 3 weeks ( topical steroids), seek medical care if s/sy persist
- OTC, do not inadvertently combine drugs leading to overdose
- Provide safety measures
DECONGESTANTS
Other measures to help relieve the discomfort of congestion:
- Humidity
- Fluids
- Cool environment
- Avoid smoke – filled areas
- Peppermint may be used as nasal decongestant
DECONGESTANTS
MOA: selectively block the effect of histamine – 1 receptor sites = decrease allergic response (itchy eyes, swelling, congestion, drippy nose) - Have anti- cholinergic and anti- pruritic effects
ANTIHISTAMINES
have greater anti- cholinergic effect with resultant drowsiness
FIRST GENERATION (ANTIHISTAMINES)
azatadine (Optimine)
FIRST GENERATION (ANTIHISTAMINES)
cetirizine ( Reactine)
FIRST GENERATION (ANTIHISTAMINES)
diphenhydramine (Benadryl)
FIRST GENERATION (ANTIHISTAMINES)
promethazine (Phenergan)
FIRST GENERATION (ANTIHISTAMINES)
desloratadine (Clarinex)
SECOND GENERATION (ANTIHISTAMINES)
fexofenadine (Allegra)
SECOND GENERATION (ANITHISTAMINES)
loratadine (Claritin)
SECOND GENERATION (ANTIHISTAMINES)
CI: pregnancy & lactation, hepatic & renal impairment, caution with cardiac arrhythmias (increase Q-T intervals)
ANTIHISTAMINES
AE: drowsiness & sedation, drying of respiratory and GI mucous membrane (skin eruption and itching), arrhythmias, dysuria, urinary hesitancy, GI upset, nausea, thickening of mucous, difficulty coughing, tightening of the chest
ANTIHISTAMINES
NURSING ACTIONS:
➔ Administer on an empty stomach
ANTIHISTAMINES
NURSING ACTIONS:
➔ Response is individualized
ANTIHISTAMINES
NURSING ACTIONS:
➔ Response is individualized
ANTIHISTAMINES
NURSING ACTIONS:
➔ Frequent mouth care (dry mouth may
lead to anorexia & nausea) ex.
sugarless candy and lozenges
ANTIHISTAMINES
NURSING ACTIONS:
Take at bedtime or safety measures if
taken during the day
ANTIHISTAMINES
NURSING ACTIONS:
➔ Do not drive
ANTIHISTAMINES
NURSING ACTIONS:
Do not operate dangerous machinery
Increase humidity
ANTIHISTAMINES
NURSING ACTIONS:
➔ Place pans of water throughout the
house
ANTIHISTAMINES
NURSING ACTIONS:
Avoid smoke filled area
ANTIHISTAMINES
NURSING ACTIONS:
➔ Increase oral fluid intake
ANTIHISTAMINES
NURSING ACTIONS:
➔ Void before each dose
ANTIHISTAMINES
NURSING ACTIONS
➔ Skin care
ANTIHISTAMINES
NURSING ACTIONS:
➔ Caution to avoid excessive dosage of
other OTC
ANTIHISTAMINES
NURSING ACTIONS:
➔ Avoid alcohol
ANTIHISTAMINES
- It is used for dry, non productive cough
EXPECTORANTS