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Pharmacology > Drugs for Pain > Flashcards

Drugs for Pain Flashcards

1
Q

List 3 types of anesthesia.

A
  1. General: inhaled or intravenous
  2. Local: administered through injection or by topical administration
  3. Regional: involves numbing a large area of the body - spinal anesthesia
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2
Q

Novacane is an example of a _____ anesthetic.

A

Local

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3
Q

List 7 characteristics of an IDEAL general anesthetic .

A
  1. Loss of consciousness/ sensation
  2. Analgesia
  3. Amnesia
  4. Skeletal muscle relaxation
  5. Inhibition of sensory/ autonomic reflexes
  6. Rapid onset
  7. Non-toxic
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4
Q

An ideal general anesthetic should achieve desired effect WITHOUT producing what 4 conditions?

A
  1. Hypoxia
  2. Laryngospasm
  3. Excessive tracheobronchial secretions
  4. Depressed respirations
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5
Q

True or False: There is a single anesthetic that can achieve the desired anesthetic effect on its own.

A

FALSE

There is no one drug that can achieve the desired effect on its own. NEED BALANCED ANESTHESIA

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6
Q

What is balanced anesthesia?

A

Involves giving several different medications in small amounts to produce desired effects while minimizing toxic effects.

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7
Q

What are the 4 stages of anesthesia?

A
  1. Analgesia
  2. Delirium
  3. Surgical anesthesia
  4. Cardiovascular/ respiratory collapse
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8
Q

______ can occur as a result of a patient falling too deep into surgical anesthesia.

A

Cardiovascular and respiratory distress

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9
Q

List 6 drugs/considerations given as premedication prior to anesthesia.

A
  1. Sedation-benzodiazepine/ barbiturate
  2. Analgesia: opioids
  3. Antiemesis: promethazine (anti-vomiting drug)
  4. Infection control: usually a single injection within an hour of the start of surgery
  5. Disease-modifying agents: e.g. pretreatment with bronchodilators for COPD
  6. Withhold certain drugs like oral diabetic drugs to avoid hypoglycemia
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10
Q

What are 2 theories that may explain the mechanism of action of inhaled anesthetics?

A
  1. Molecules of gas dissolve in the neuronal membrane causing the membrane to expand impeding the opening of ion channels (so no AP can occur)
  2. Probably act differently in different neural tissues and affect a variety of ion channels. Anesthetic-sensitive potassium (K+) channel is understudy
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11
Q

What 2 effects can inhaled anesthetics have on the cardiovascular system?

A
  1. Most decrease arterial pressure

2. Depress contractility producing reflex tachycardia

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12
Q

What 2 effects can inhaled anesthetics have on the pulmonary system?

A
  1. Decrease RR

2. Decreased mucociliary function

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13
Q

What 2 effects can inhaled anesthetics have on the central nervous system?

A
  1. Decrease metabolic rate

2. Increased cerebral blood flow

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14
Q

What 2 effects can inhaled anesthetics have on the renal and hepatic systems?

A
  1. Renal: decrease glomerular filtration rate

2. Hepatic: decrease blood flow

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15
Q

Inhaled anesthetics can induce ________.

A

Malignant Hyperthermia

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16
Q

What are 4 symptoms associated with malignant hyperthermia?

A
  1. Excessive muscular rigidity
  2. Producing high BP
  3. Tachycardia
  4. Fast rise in fever
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17
Q

List 3 treatments used to treat malignant hyperthermia.

A
  1. Dantrolene
  2. Lidocaine
  3. Cooling blanket
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18
Q

_____ is an ultra-short acting barbituate (IV anesthesia). This drug is often replaced with ____.

A

Thiopental

Propofol

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19
Q

What is the MOA of IV anesthesia? (4)

A

Binds to GABAa gated Chloride Channels

  1. Induce anesthesia
  2. Produce hypnosis
  3. Anesthesia without analgesia.
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20
Q

What is the dosing of IV anesthesia?

A
  1. IV injection

2. Rapidly taken up by brain (30 sec) short duration (10 min) due to redistribution in fat

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21
Q

List 5 ADRs associated with IV anesthesia.

A
  1. Hangover due to lipid solubility
  2. Respiratory depression
  3. Bronchospasm
  4. Laryngospasm
  5. Reflex tachycardia
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22
Q

IV anesthetic drugs may need to be given with _____. Why?

A

Opioids

Why?: Anesthetics may not produce analgesia, which is why you need an opioid to relieve the pain.

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23
Q

Large doses of _____ can induce anesthesia while maintaining a good _____ but impairing ______.

A

IV Opioids

Cardiovascular profile

Ventilation (depress RR)

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24
Q

____ are too slow in onset but can provide basal level of sedation for maintenance of anesthesia

A

Benzodiazepines

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25
Q

What drug, given 30-60 min before surgery, can be used to produce anterograde amnesia?

A

Midazolam with an anxiolytic

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26
Q

______ may be given to inhibit any movement especially for delicate surgical procedures.

A

Neuromuscular blocker

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27
Q

List 3 TRUE IV anesthetics.

A
  1. Etomidate
  2. Ketamine
  3. Propofol
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28
Q

List 4 characteristics of Etomidate.

A
  1. Min. changes in CVS/ respiratory function
  2. Rapid induction(within 60 seconds)
  3. Can produce skeletal muscle movements
  4. Produces nausea and vomiting
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29
Q

List 4 ADRs associated with the use of ketamine.

A
  1. Dissociative anesthesia
  2. HTN
  3. Tachycardia
  4. Emergence phenomena
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30
Q

What 3 symptoms make up emergence phenomena ?

A
  1. Visual hallucinations
  2. Vivid dreams
  3. Thrashing
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31
Q

Propofol causes global CNS _____ through agonist actions on _____.

A

Depression

GABAa

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32
Q

List 4 characteristics of Propofol.

A
  1. Lowers BP without myocardial depression
  2. Lowers intracranial pressure
  3. Good anti-emetic action
  4. Used for same day surgery and examinations (colonoscopy)
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33
Q

General anesthetics depress ______ in the airways leading to pooling of mucus. List 3 PT interventions used to treat this.

A

Mucociliary clearance

  1. Breathing exercises
  2. Coughing
  3. Proper guarding with ambulation
34
Q

What is the difference between regional and local anesthesia?

A
  1. Regional: administration of local agent and includes IV regional block/epidural or spinal administration
  2. Local: topical anesthesia, infiltration anesthesia, peripheral nerve block
35
Q

List 3 advantages of local anesthesia.

A
  1. Quick recovery
  2. Pt remains conscious
  3. Does not interfere with cardiovascular, respiratory, and renal function
36
Q

List 2 disadvantages of local anesthesia.

A
  1. Incomplete analgesia

2. Time to achieve anesthesia

37
Q

What is the MOA of local anesthetics? What is an indication for the use of local anesthetics?

A

MOA: Block sodium channels: Smaller C fibers are affected first, then type A delta

  1. Indication: Pain relief for local surgery (suture repair/ dental work)
38
Q

True or False: Local anesthetics RARELY produce ADRs.

39
Q

List 4 ADRs associated with low dose local anesthetics.

A
  1. Sleepiness
  2. Light-headedness
  3. Visual/auditory disturbances
  4. Restlessness
40
Q

List 2 ADRs associated with high dose local anesthetics.

A
  1. Neurotoxicity

2. Produce generalized excitation followed by profound CNS depression

41
Q

List 6 pain mediating substances that are released following tissue injury to stimulate afferent receptors/neurons.

A
  1. K+
  2. Serotonin
  3. Histamine
  4. Bradykinin
  5. Prostaglandins
  6. Leukotrienes
42
Q

Pain Transmission

A

REFER TO DIAGRAM ON SLIDE 16 (IMPORTANT)

43
Q

List 4 characteristics of opioids.

A
  1. Any substance that relieves pain
  2. Acts on Mu receptor
  3. Action is reversed by naloxone
  4. Mimic endogenous opioids, endorphins, and enkephalins
44
Q

List the 3 classes of opioid receptors.

A
  1. Mu
  2. Delta
  3. Kappa
45
Q

List 7 probable effects of stimulating Mu opioid receptors.

A
  1. Produces analgesia euphoria
  2. Associated with respiratory depression
  3. bradycardia
  4. Emesis
  5. Constipation
  6. Sedation
  7. Meiosis
46
Q

List 3 probable effects of stimulating delta opioid receptors.

A
  1. Produces analgesia, euphoria (but less than Mu), 2. Sedation
  2. Decreased GI motility, respiratory
47
Q

List 6 probable effects of stimulating kappa opioid receptors.

A
  1. Produces analgesia
  2. Sedation
  3. Dyspnea
  4. Dependence
  5. Dysphoria
  6. Inhibition of ADH release
48
Q

All opioid receptors open ____ channels causing hyperpolarization and a decrease in ________.

A

Potassium

Nerve transmission

49
Q

What is inhibited when hyperpolarization occurs as a result of opioid receptors opening potassium channels?

A

Inhibit the opening of calcium channels inhibiting release of substance P

50
Q

Opioids are involved in the _____ systems to produce euphoria.

A

Mesolimbic dopamine system

51
Q

What is the MOA of strong agonists like morphine/heroine?

A

Binds to mu and Kappa receptors.

52
Q

List 4 effects associated with strong agonists (morphine/ heroine).

A
  1. Analgesia
  2. Sedation
  3. Euphoria (80%)
  4. Dysphoria (20%)
53
Q

List 7 indications for the use of strong agonists (morphine).

A
  1. Acute pain
  2. HF-due to peripheral vasodilation
  3. MI (to reduce cardiac workload)
  4. Cough
  5. Antidiarrheal effect
  6. Acute pulmonary edema
  7. Anesthesia
54
Q

List 3 benefits of strong agonists (morphine).

A
  1. Pain relief
  2. Cough suppression
  3. Arterial vasodilator in HF and MI
55
Q

List 7 ADRs associated with the use of strong agonists (morphine).

A 
sleepiness
•vomiting (chemoreceptor trigger zone in medulla)
•increased sweating
•hypotension & bradycardia
•depressed respiration: most common reason for death
•constipation
•urinary retention
•frictopathia (from release histamine)
56
Q

______ is a mild to moderate agonist for moderate pain.

57
Q

List 2 characteristics of codeine.

A
  1. Binds to mu and kappa receptors but with reduced affinity
  2. Produces same level of constipation and respiratory depression as morphine
58
Q

Tramadol oral opioid that blocks reuptake of ____ and ____. It can cause addiction.

A

Norepinephrine

5HT (serotonin)

59
Q

How is patient controlled analgesia administered?

A

Allows the patient to self administer the drug on an as needed basis usually with a preprogrammed continuous infusion pump

60
Q

What are 2 advantages of using patient controlled transdermal fentanyl patch using iontophoresis?

A
  1. No tubing

2. Improved mobility for patients

61
Q

Why is fixed interval administration more effective than dosing on demand?

A

Keeps the pain from building up

62
Q

_____ has large first-pass effect compared to oral codeine and oxycodone therefore preferred route of administration of morphine is ____.

A

Morphine

IV

63
Q

Once absorbed, opioids distributed to ______ and accumulate in ______.

A

Distributed to highly perfused tissues (brain)

Accumulate in fatty tissue

64
Q

List 2 opioid metabolizing enzymes.

A
  1. CYP3A4 P450 metabolize fentanyl producing non-active metabolites
  2. CYP2D6 P450 metabolizes oxycodone and hydrocodone producing active metabolites with greater affinity
65
Q

What is tolerance? When does it typically begin?

A
  1. Develops quickly and patient must continually administer a higher dose to get the same effect.
  2. Begins after the first administration and often an increase in dose is needed in just 2-3 weeks
66
Q

What is physical dependence? List 13 sxs a patient may experience as a result of withdrawal.

A

Implies that when drug is withdrawn

  1. Anxiety
  2. Irritability
  3. Hot flashes alternating with chills
  4. Body aches
  5. Runny nose
  6. Diarrhea
  7. Shivering
  8. Gooseflesh
  9. Stomach cramps
  10. Insomnia
  11. Sweating
  12. Tachycardia
  13. Nausea
  14. Yawning.
67
Q

What is addiction?

A

Deliberately seeking out a drug for its mood-altering abilities

68
Q

How is withdrawal treated?

A
  1. methadone or buprenorphine and/or naltrexone

2. Once patient is stabilized on these, the dose is reduced 5-10% every 1-2 weeks

69
Q

What is methadone?

A

Synthetic opioid that blocks heroin from binding to the receptor and prevents withdrawal symptoms

70
Q

True or False: Methadone does not produce euphoria.

71
Q

What is the half-life of methadone?

A

Longer half-life, 1-2 days compared to 4-6 hours for heroin

72
Q

List 2 risks associated with using methadone.

A
  1. Prolong QT interval and arrhythmias

2. When combined with a serotonin reuptake inhibitor, may cause serotonin syndrome

73
Q

True or False: Withdrawal from long-acting opioid is much easier than withdrawal from a short-acting opioid

74
Q

What is the MOA of buprenorphine?

A

Binds to m receptor but has lower efficacy than the other opioids, also agonist at delta receptor but antagonist at Kappa receptor

75
Q

What happens when heroin is injected on top of buprenorphine?

A

Produces less euphoria since there are less free receptors to bind heroin

76
Q

Buprenorphine is used to prevent withdrawal from ______ opioids.

A

Long-acting opioids

77
Q

What is the difference between naltrexon and naloxone (morphine antagonists)?

A

Naltrexone is similar but has a longer duration of action (t1/2 = 10 hrs)and can be used after detox to help reduce patient’s cravings

78
Q

When should therapy be scheduled in patients taking opioids?

A

Schedule therapy when opioid has nearly reached its peak action so that the patient can cooperate but still be able to accurately report pain

79
Q

Opioids should be prescribed at the lowest possible dose and for ___ days for acute pain and then re-evaluate.

80
Q

What tool can be used to assist the prescriber in determining risk for deviant behavior by patients who will be receiving opioids for chronic pain?

A

Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R)

Pharmacology (12 decks)

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