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Neuro II > Drugs for Movement Disorders - Kruse > Flashcards

Drugs for Movement Disorders - Kruse Flashcards

1
Q

T1/2: Bromocriptine

A

15 h

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2
Q

Peak [plasma]: bromocriptine

A

1-3 h

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3
Q

metabolism: bromocriptine

A

CYP3A4 - extensive first pass

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4
Q

benefit of dopamine antagonist

A

lower incidence of response fluctuations and dyskinesia in comparison to LT L-dopa tx

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5
Q

MOA: Pramipexole

A

D3 receptor agonist

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6
Q

Tx; Pramipexole

A

RLS

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7
Q

peak [plasma]: pramixole

A

2h

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8
Q

T1/2: pramipexole

A

8h

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9
Q

ROE: pramipexole

A

90% in urine

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10
Q

MOA: ropinirole

A

D2 receptor agonist

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11
Q

tx: ropinirole

A

RLS

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12
Q

Met: ropinirole

A

primarily CYP1A2

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13
Q

T1/2: ropinirole

A

6h

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14
Q

peak [plasma]: ropinirole

A

1-2h

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15
Q

Dopamine receptor agonists

A
  • bromocriptine
  • pramipexole
  • ropinirole
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16
Q

AEs: Dopamine Agonists

A
  • GI: anorexia, nausea, vomiting
  • postural hypotenstion
  • peripheral edema + cardiac arrhythmias = stop using
  • more severe mental dist than w/ L-dopa
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17
Q

CIs: Dopamine agonists

A
  • psychosis
  • recent MI
  • active peptic ulcers
  • periperal vascular dz (bromocriptine)
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18
Q

MOA: Selegiline

A

selective, irreversible MAO-Bi

19
Q

MOA: Rasagiline

A

irreversible MAO-Bi, > potent than selegiline

20
Q

CIs: Selegiline

A
  • merperidine
  • tricyclic antidepressants
  • SRIs
21
Q

AEs: Rasagline

A

hypertensive crisis when used with L-dopa

22
Q

AEs: Tolcapone

A

death from acute hepatic failure d/t increase in liver enzymes

23
Q

MOA: COMTi

A

competes with L-dopa for transport across membranes - prolongs L-Dopa activity by inhibiting peripheral metabolism

24
Q

AE: Amatadine

A

livedo reticularis: purplish mottled disocloration of skin, usually legs

25
Q

CIs: Amatadine

A

use with caution in pts with hx of seizures and heart failure

26
Q

Anticholinergics used for PD tx

A
  • benztropine
  • biperiden
  • orphenadrine
  • procyclidine
  • trihexphenidyl
27
Q

Tx: anticholinergics for PD

A

may improve tremor and rigidity, little effect on bradykinesia

28
Q

beta-blockers used for tremor

A

metoprolol and propranolol (beta 1)

29
Q

AEDs to tx tremor

A

pirimidone and topirimate

30
Q

Pyschoactive drug used to tx tremor

A

benzodiazepines

31
Q

IM injection used to tx tremor

A

botox

32
Q

drugs used to manage choria in HD pts

A
  • reserpine
  • tetrabenazine
  • olanzapine
  • perphenazine
  • haloperidol
33
Q

neuroletic antipsychotics used for tics

A
  • tetrabenzaine
  • haloperidol
  • pimozide
34
Q

alpha-andrenergic tx for tics

A
  • clonidine

- guanfacine

35
Q

only FDA approved tx for RLS

A
  • prampexole

- ropinirole

36
Q

MOA: Riluzole

A
  • inhibits glutamate release
  • blocks postsynaptic NMDA and kainite-type glutamate receptors
  • inhibits VGNaCs
37
Q

Tx: riluzole

A

ALS

38
Q

Tx: penicillamine

A

wilson’s dz

39
Q

MOA: Penicillamine

A

Cu chelating agent

40
Q

AEs: Penicillamine

A
  • nausea
  • vomiting
  • nephritic syndrome
  • myasthenia
  • optic neuropathy
  • various blood disorders
41
Q

tx: potassium disulfide

A

wilsons dz

42
Q

MOA: potassium disulfide

A

reduces intestinal absorption of copper

43
Q

MOA: Bromocriptine

A

D2 agonist (ergot alkaloid)

Neuro II (12 decks)

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