Drugs for Lipid Disorders

Question 1

Which classes will you see increases in aminotransferases?

Answer 1

1. Statins (3x) 2. Niacin 3. Lomitapide

Question 2

Which classes will you see increases in aminotransaminases?

Answer 2

1. Fibrates (3x)

Question 3

What do lomitapide and mipomersin treat?

Answer 3

Familial hypercholesteremia

Question 4

Which drug is a substrate and inhibitor of CYP P450?

Answer 4

Lomitapide

Question 5

MOA of mipomersin

Answer 5

1. Mipomersin is an antitense oligonucleotide that inhibits Apo-B mRNA => inhibit formation of Apo-B mRNA.

Question 6

Fibrates SE

Answer 6

1. GI
2. Increase risk of cholelithiasis d/t increase of cholesterol in bile

Question 7

PCSK9 inhibitors

MOA

Answer 7

1. Monoclonab AB that binds to the LDL receptor in the liver and prevent its degradation.
2. Increases LDL removed from blood

Question 8

List the 4 therapeutic benefits of HMG-CoA reductase inhibitors (statins)?

Answer 8

1. Stabilize plaques
2. Improve function of coronary endothelial cells
3. Anti-inflammatory
4. Prvent thrombus formation

Question 9

incrase creatine kinase levels in someone who works out. what drug are they taking?

Answer 9

Statin

Question 10

Which drug will you see greatest increase in HDL

Greatest decrease in LDL

Greatest decrease in TAGS

Answer 10

1. Niacin
2. Statin
3. Fibrates

Question 11

Fibrates are useful in the management of which 3 lipid disorders?

Answer 11

• Hypertriglyceridemias where VLDL predominates
• Dysbetalipoproteinemia
• Hypertriglyceridemia resulting from tx w/ viral protease inhibitors (i.e., saquinavir, indinair, or nelfinavir for HIV therapy)