Drugs for Hyper tension Flashcards
What are the classes of drugs we learned for Hypertension (6)
1) Loop dieretics -> K plus sparing, loop, thiazides
2) Inhibitors of RAAS
3) Calcium channel blockers
4) Adrenergic receptor anatagonsits
5) direct vasodilators
6) central acting agents
What are the types of inhibitors of RAAS that we know (4)
1) ACEi
2) Angiotensin Receptor blocekrs
3) REnin inhibitors
4) Aldosterone receptor antagonists
What is the ending of ACEi
“pril”
example
Ramipril
Adverse side effects of ACEi (5)
1) cough -> bradykinin thing
2) Hypotension
3) Hyperkalemia
4) renal dysfunction
Angioedema
Contraindications of ACEi (2)
1) Pregnancy
2) renal artery stenosis
ARB Angiotensin receptor blockers End with what
“tan” losartan
Angiotensin receptor blockers side effects (4)
1) less cough and less angioedema
2) dizziness and headaches
3) hyperkalemia
4) renal dysfunction
Angiotensin receptor blockers Contraindications (1)
1) Pregnant
What does renin inhibitors end with
“ren”
Side effects renin inhibitors
Diarrhea and angioedema
Contraindications for renin inhibitors
pregnancy
What are the two types of Calcium channel blockers
1) dihydropyridines
2) non-dihydropyridines
What is the MOA of Calcium channel blockers
Decrease HR contraction
dilate SM in vessels
Decrease ca signalling to adrenal decrease release of aldosterone
Side effects Ca channel blockers
1) Bradycardia and hypotension-> decreased HR
2) dizziness and headache
3) flushing, peripheral edema, reflex tachycardia-> vasodilation
What are contraindication for dihydropyridiens
conditions worsened by tachycardia
severe aortic stenosis
Contraindication for non-dihydropyridiens
wolf-parkinisd whie syndrome and av blocks
actue CHF
Sorta can be used for pregnancy
What are the 3 adrenergic receptors and their function
1) B1-> increases contraction HR and renin secretion
2) B2-> bronchodilator vasodilation of skeletal muscles arterioles
3) A1-> vasoconstriction and vasoconstriction of non-skeletal muscle vessels
(4) types of Beta-blockers
1) Cardioselevtive-> B1 only
2) non-cardio selective_ B2 and B1
3) Mixed alpha and Beta-blockers _> A1 B1 B2
4) partial agonist (b1 agonist)
What do beta-blockers end with
Lol
Side effects of beta-blockers
1) fatigue
2) bradycardia
3) bronchoconstrction
4) rebond hypertension
Contraindication for beta-blockers
Astham\braydcardia
acute CHF
Alpha 1 blocker ending
“sin”
Central acting agent ending
“dine
MOA central acting agent
inhibit presynaptic release of norepinephrine decrease svr hr and sv
