Drugs For Amoebiasis, toxoplasma

Question 1

Luminal agents

Answer 1

Diloxanide furoate
Iodoquinol
Paromomycin

Question 2

Indication for surgical drainage of amoebic abscess

Answer 2

Abscess is 5cm or greater in diameter
If located in left lobe
No clinical response to medicl therapy

Question 3

Moa of luminal amebicides

Answer 3

Paromomycin - inhibits protein synthesis; binds to 16s ribosomal subunit
Diloxanide furoate - unknown
Iodoquinol - unknown

Question 4

Drug of choice of asymptomatic cyst carriers of E histolytica

Answer 4

Diloxanide furoate

Backup is paromomycin

Question 5

Indications for paromomycin

Answer 5

Asymptomatic cyst carriers (backup)
Intestinal amebiasis
Cryptosporodiosis

Question 6

MOA of metronidazole

Answer 6

Reactive reduction by ferredoxin forming FREE RADICALS that disrupt ETC; tissue amebicide

Question 7

Tissue amebicides

Answer 7

Metronidazole
Nitazoxanide
Emetine
Dehydroemetine

Question 8

Drug of choice for cryptosporidiosis

Answer 8

Nitazoxanide

Alt: paromomycin

Question 9

MOA of sulfamethoxazole and sulfadiazine

Answer 9

Inhibits dihydropteroate synthase

Question 10

MOA of trimethoprim and pyrimethamine

Answer 10

Inhibits dihydrofolate reductase

Question 11

Drug of choice for toxoplasmosis

Answer 11

Sulfadiazine + pyrimethamine

Question 12

At what level is co-trimoxazole recommended in HIV

Answer 12

CD4 < 200

Prophylaxis for pneumocystis and toxoplasma