Anti-virals Flashcards
Maraviroc
Blocks CCR5
Attachment inhibitor
Fusion inhibitos
Enfuvirtide (GP41)
Docosanol (anti-HSV)
Penetration inhibitor
Interferon-a (HBV, HCV)
-activates host cell RNAse
Seps in viral replication and protein synthesis
- Attachment and entry
- Penetration
- Uncoating
- Nucleic acid synthesis
5 integration (retrovirus) transcription - Viral protein synthesis
- Packaging and assembly
- Viral release
Uncoating inhibitors
Amantadine and rimantadine
-for influenza A only
Amantadine also used in parkinsonism
Amantadine - livido reticularis 😡
Integrase inhibitors
Raltegravir
Protease inhibitors
Ritonavir
Indinavir - hyperbilirubinemia, nephrolithiasis
Saquinavir
Lopinavir
*class effect: hyperlipidemia, hyperglycemia
Release inhibitors
Neuraminidase inhibitors *for both Influenza A and B Oseltamivir Zanamivir Peramivir
Describe NRTI
Inhibits HIV reverse transcriptase after phosphorylation by cellular enzymes
Causes lactic acidosis + hepatic statosis
List NRTI
Lamivudine - also for HBV Ziduvudine - anemia/bm suppression Stavudine Emtricitabine Zalcitabine Abacavir - hypersensitivity Tenofovir - also for HBV Didanosine - PANCREATITIS
Describe NNRTI
No need for phosphylation for activation
“No bm suppression in NNRTI bec they are NOT incorporated in DNA”
List NNRTI
Nevirapine - inc AST, ALT
Efavirenz - teratogen
Etravirine - inc chole, TG
Delavirdine - inc AST, ALT
Drugs for influenza
Uncoating inh Amantadine Rimantadine Neuraminidae inh Oseltamivir Zanamivir
Drugs for HBV/HCV
Entecavir (for severe acute hepa B)
Tenofovir (for severe acute hepa B; NRTI)
Lamivudine (NRTI)
Ribavirine (also for RSV)
Drug for RSV
RIBAVIRIN -inhibits GTP -prevents capping of viral mRNA -blocks RNA-dep RNA polymerase -s/e: hemolytic anemia, conjunctival, bronchial irritation PALIVIZUMAB
