Drugs enhancing GABA systems Flashcards

1
Q

triazolam

A

Benzodiazepine

  • duration of action: short
  • treat insomnia
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2
Q

temazepam

A

Benzodiazepine

  • duration of action: medium
  • treat insomnia
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3
Q

diazepam

A

Benzodiazepine

  • duration of action: long
  • treat anxiety, seizures, muscle spasm, preanesthesia. alcohol and opiate “detoxification & reversal of addiction”
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4
Q

chlordiazepoxide

A

Benzodiazepine

  • duration of action: long
  • treat anxiety, alcohol and opiate “detoxification & reversal of addiction”
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5
Q

lorazepam

A

Benzodiazepine

  • duration of action: medium
  • treat anxiety, preanesthesia
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6
Q

alprazolam

A

Benzodiazepine

  • duration of action: medium
  • treat anxiety, panic disorders
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7
Q

clonazepam

A

Benzodiazepine

  • duration of action: very long
  • treat seizures
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8
Q

midazolam

A

Benzodiazepine

  • duration of action: short
  • treat preanesthesia, anesthesia
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9
Q

oxazepam

A

Benzodiazepine

-duration of action: short

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10
Q

flumazenil

A

treatment for benzodiazepine overdose side effect

-bz antagonist (binds on the same site on the GABA receptor as bz and blocks bz effect)

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11
Q

phenobarbital

A

Barbiturate

  • oral or intravenous
  • medium onset, long duration
  • sedative, hypnotic, antiepileptic
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12
Q

pentobarbital

A

Barbiturate

  • intravenous
  • short onset, medium duration
  • sedative, hypnotic, anesthetic
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13
Q

thiopental

A

Barbiturate

  • intravenous
  • ultrashort onset, short duration
  • anesthetic
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14
Q

zolpidem

A

Other hypnotics: acting at GABA receptor

  • everything same as benzodiazephine (except it is not bz)
  • not used for other uses of bz/barbiturates
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15
Q

eszopiclone

A

Other hypnotics: acting at GABA receptor

  • everything same as benzodiazephine (except it is not bz)
  • not used for other uses of bz/barbiturates
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16
Q

zaleplon

A

Other hypnotics: acting at GABA receptor

  • everything same as benzodiazephine (except it is not bz)
  • not used for other uses of bz/barbiturates
17
Q

ramelteon

A

Other hypnotics: NOT acting at GABA receptor

  • no interaction with GABA receptor
  • agonist at melatonin receptors (melatonin = “natural” sleep inducer)
  • not used for other uses of bz/barbiturates
18
Q

doxepin

A

Other hypnotics: NOT acting at GABA receptor

  • no interaction with GABA receptor
  • agonist at histamine H1 & H2 receptors
  • not used for other uses of bz/barbiturates
19
Q

buspirone

A

Other anxiolytic: NOT acting at GABA receptor

  • no interaction with GABA receptor
  • only useful as anxiolytic
  • agonist at 5HT(1A) receptor
  • not immediate effect (1-2 weeks delay)
  • not used for other uses of bz/barbiturates