Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHM Exam 3 > Cancer Chemo Drugs > Flashcards

Cancer Chemo Drugs Flashcards

1
Q

cyclophosphamide

A

Alkylating Agents: DNA targetting drugs -“Nitrogen Mustards” -affect cells at any stage -transfer alkyl group to DNA (guanine) and inhibit replication and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mechlorethamide

A

Alkylating Agents: DNA targetting drugs -“Nitrogen Mustards” -affect cells at any stage -transfer alkyl group to DNA (guanine) and inhibit replication and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

chlorambucil

A

Alkylating Agents: DNA targetting drugs -“Nitrogen Mustards” -affect cells at any stage -transfer alkyl group to DNA (guanine) and inhibit replication and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

carmustine

A

Alkylating Agents: DNA targetting drugs -“Nitrogen Mustards” -affect cells at any stage -transfer alkyl group to DNA (guanine) and inhibit replication and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

lomustine

A

Alkylating Agents: DNA targetting drugs -“Nitrogen Mustards” -affect cells at any stage -transfer alkyl group to DNA (guanine) and inhibit replication and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

cisplatin

A

Alkylating Agents: but not really… -similar to an alkylating agent in mechanism (DNA targetting drug) and effect -inhibit DNA replication and function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

mitomycin

A

Alkylating Agents: but not really… -antabiotic -binds DNA and cause strand breakage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

6 mercaptopurine

A

Antimetabolites: purine analogs -prevent DNA synthesis and produce a defective one by substituting normal substrates for synthesis -produce abnormal DNA -bind to and inhibit enzymes for synthesis of Adimine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

thioguanine

A

Antimetabolites: purine analogs -prevent DNA synthesis and produce a defective one by substituting normal substrates for synthesis -produce abnormal DNA -bind to and inhibit enzymes for synthesis of Guanine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

5 fluorouracil

A

Antimetabolites: pyrimidine analogs -prevent DNA synthesis and produce a defective one by substituting normal substrates for synthesis -produce abnormal DNA -bind to and inhibit enzymes for synthesis of Thymidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

cytosine arabinoside

A

Antimetabolites: pyrimidine analogs -prevent DNA synthesis and produce a defective one by substituting normal substrates for synthesis -produce abnormal DNA -bind to and inhibit enzymes for synthesis of Cytosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

methotrexate

A

Antimetabolites: folic acid analogs -prevent DNA synthesis and produce a defective one by substituting normal substrates for synthesis -produce abnormal DNA -bind and inhibit dihydrofolate reductase -inhibit thymide synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

vinblastine

A

Mitotic inhibitor: cell cycle specific agent -MITOSIS (chromosomal division) -disruption of chromosome separation in mitosis -produce therapeutic effect non cell cycle specific -general disruption of cytoskeletal “motors” -produce side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

vincristine

A

Mitotic inhibitor: cell cycle specific agent -MITOSIS (chromosomal division) -disruption of chromosome separation in mitosis -produce therapeutic effect non cell cycle specific -general disruption of cytoskeletal “motors” -produce side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

paclitaxel

A

Mitotic inhibitor: cell cycle specific agent -MITOSIS (chromosomal division) -disruption of chromosome separation in mitosis -produce therapeutic effect non cell cycle specific -general disruption of cytoskeletal “motors” -produce side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

etoposide

A

DNA topoisomerase inhibitor: cell cycle specific agent -S phase -inhibit bacterial DNA topoisomerase critical in DNA maintenance and replication

17
Q

teniposide

A

DNA topoisomerase inhibitor: cell cycle specific agent -S phase -inhibit bacterial DNA topoisomerase critical in DNA maintenance and replication

18
Q

estrogen

A

Hormonal agents: agonist at estrogen receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: prostate gland cancer, breast cancer -side effects: used as contraceptives in females, feminization in males

19
Q

diethylstibestrol

A

Hormonal agents: agonist at estrogen receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: prostate gland cancer, breast cancer -side effects: feminization in males

20
Q

androgens

A

Hormonal agents: agonist at androgen receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: breast cancer -side effects: edema, masculinization in females

21
Q

testosterone

A

Hormonal agents: agonist at androgen receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: breast cancer -side effects: edema, masculinization in females

22
Q

fluoxymestrone

A

Hormonal agents: agonist at androgen receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: breast cancer -side effects: edema, masculinization in females

23
Q

progestin

A

Hormonal agents: agonist at progestin receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: renal carcinoma, endometrial carcinoma -side effect: used as contraceptives in women

24
Q

hydroxyprogesterone

A

Hormonal agents: agonist at progestin receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: renal carcinoma, endometrial carcinoma

25
Q

medroxyprogesterone

A

Hormonal agents: agonist at progestin receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: renal carcinoma, endometrial carcinoma

26
Q

megestol

A

Hormonal agents: agonist at progestin receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: renal carcinoma, endometrial carcinoma

27
Q

corticosteroids

A

Hormonal agents: agonist at glucocorticoid receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: childhood leukemia, lymphoma, some breast cancers -side effects: osteoporosis, fluid retention & hypertension, hyperglycemia

28
Q

prednisone

A

Hormonal agents: agonist at glucocorticoid receptors -agonist: mimics endogenous hormone agonist –> slow cell replication -uses: childhood leukemia, lymphoma, some breast cancers -side effects: osteoporosis, fluid retention & hypertension, hyperglycemia

29
Q

anti estrogen

A

Hormonal agents: estrogen receptor antagonist -antagonist: inhibits endogenous hormone agonist which enhances cell replication -uses: breast cancer

30
Q

tamoxifen

A

Hormonal agents: estrogen receptor antagonist -antagonist: inhibits endogenous hormone agonist which enhances cell replication -uses: breast cancer

31
Q

anti androgen

A

Hormonal agents: androgen receptor antagonist -antagonist: inhibits endogenous hormone agonist which enhances cell replication -uses: metastatic prostate cancer

32
Q

flutamide

A

Hormonal agents: androgen receptor antagonist -antagonist: inhibits endogenous hormone agonist which enhances cell replication -uses: metastatic prostate cancer

33
Q

erlotinib

A

Tyrosine kinase inhibitors: non “DNA targeting” drugs -TK inhibition found to be useful in tumors

34
Q

imatinib

A

Tyrosine kinase inhibitors: non “DNA targeting” drugs -TK inhibition found to be useful in tumors

35
Q

rituximab

A

Monoclonal antibody: non “DNA targeting” drug -antibody causes cell death by targeting abnormal, cell-surface protein -ab targets cell growth factor

36
Q

trastuzumab

A

Monoclonal antibody: non “DNA targeting” drug -antibody causes cell death by targeting abnormal, cell-surface protein -ab targets cell growth factor

37
Q

bevacizumab

A

Monoclonal antibody: non “DNA targeting” drug -antibody causes cell death by targeting abnormal, cell-surface protein -ab targets cell growth factor

PHM Exam 3 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions