Drugs & Doses: Lifestyle Changes

Question 1

Smoking Cessation Options:

Answer 1

1. Varenicline
2. NRT
3. Bupropion
   (4. Nortriptyline)

Question 2

Smoking Cessation - NRT Dosing

Answer 2

21mg/24hr patch for >45kg/10cigs
14mg/24hr patch for <45kg/10cigs
aim to cease 12/52

Question 3

Smoking Cessation - Varenicline Dosing

Answer 3

0.5mg for 3/7 -> 0.5mg BD for 4/7, then 1mg BD for 12/52. Start 1/52 before quit date

Question 4

Smoking Cessation - Bupropion Dosing

Answer 4

150mg daily for 3/7, then 150g BD for 9/52. CI in seizures

Question 5

Smoking Cessation - Nortriptyline Dosing

Answer 5

25-75mg daily, start 10-28 days before quit date, course of 12/52

Question 6

EtOH Cessation Options:

Answer 6

Disulfiram
Acamprosate
Naltrexone

Question 7

EtOH Cessation - Disulfiram Dosing + mechanism?

Answer 7

100mg daily up to 300mg - blocks EtOH metabolism - feels like crap
NOT IN OZ NO MORE

Question 8

EtOH Cessation - Acamprosate Dosing + mechanism?

Answer 8

666mg TDS (>60kg) - reduces withdrawal symptoms

Question 9

EtOH Cessation - Naltrexone Dosing + mechanism?

Answer 9

50mg daily - less pleasurable effects. CI in chronic opioid users

Question 10

Weight Reduction Options (Pharm + Non-Pharm):

Answer 10

Orlistat
GLP1 - liraglutide (Saxenda)
Phentermine (Duromine)
Naltrexone + Bupropion

Calorie deficit 600kCal / 1hr moderate exercise 5 days a week