Drugs and usual doses Flashcards
Schedule for Percocet
II- high potential for abuse
Schedule for Vicodin
III- moderate potential for abuse
Schedule for Tylenol #3
III moderate potential for abuse
Schedule for Darvocet
IV low potential for abuse
Percocet 5/325?
oxycodone/ acetaminopen 5mg/325mg QID
Roxicet?
Oxycodone/acetaminopen
-5mg/325mg/ 5mL
-essentially a liquid form of Percocet that is good for pediatric patients
What is the difference between Percocet and Percodan?
-Percocet has 325 acetaminophen
-Percodan haas 325 mg of ASA
Vicodin 5/500
hydrocodone/acetaminophen 5mg/500mg
QID
Tylenol #3
codeine/acetaminophen 30mg/300mg
QID
Darvocet N100
propoxyphene/acetaminophen
-100mg/650mg
q4
Ultram
Tramadol 50mg
QID
Toradol
Ketorolac 10mg
-an NSAID that should not be used more than 5 days due to possible significant side effects
Darvon
-propoxyphene
OxyContin
oxycodone extended release
Morphine sulfate
2-4mg IV QID.
-usually used for very painful dressing changes or bedside debridement
MS Contin
morphine sulfate extended release 15-30mg
Dilaudid
hydromorphone
Very strong drug
What are the therapeutic effects seen with acetaminophen (2)
analgesic and anti-pyretic
What is the maximum daily dose of acetaminophen
4grams
What therapeutic effects are seen with most NSAIDS (3)
analgesic, anti-pyretic, anti-inflammatory
What pathway do NSAIDS work on
cyclooxygenase
NSAIDS nonselectively inhibit both COX-1 and COX-2
What is the most common side effect of NSAIDs
GI disturbance ( especially if it is a strong COX-1 inhibitor)
What is the only FDA approved COX-2 inhibitor
celecoxib
-others were withdrawn due to increased risk of heart attack and stroke
Which NSAIDS only have anti-inflammatory effects
Indomethacin and tolmetin
Do NSAIDs decrease joint destruction
no they only decrease inflammation
Do NSAIDs affect bone healing
NSAIDs and COX-2 inhibitors may inhibit bone healing via their anti-inflammatory effects
What NSAID causes irreversible inhibition of platelet aggregation
aspirin
What NSAID does not inhibit platelet aggregation
the COX-2 inhibitor celebrex
What is the only IV NSAID
ketorolac (toradol)
What NSAID is often given during surgery or immediately post-op to decrease pain and inflammation
-Toradol 30mg IV
What are the NSAIDs with the least neprotoxicity
- celebrex
-Relafen
-Lodine
What is the effect of NSAIDs for a patient with asthma
- can increase the symptoms of asthma
What are the safest NSAIDs for a patient with asthma
and ketoprofen
Which NSAIDs treat collagen vascular disease
ibuprofen, sulindac, tolmetin
Which NSAIDs are not renally cleared
indomethacin and sulindac
What are the cardiovascular effects of NSAIDS
they can cause vasoconstriction and increase blood pressure
Which NSAIDs have the least cardiovascular effects
diclofenac and ketoprofen
Which NSAIDs are the most hepatotoxic
Ibuprofen, naproxen and diclofenac
What should be given for an indomethacin overdose
benadryl
-decreaes serotonin and histamine release
What is arthrotec
diclofenac and misoprostol
-an NSAID with protection for the stomach
What is the anti-inflammatory dose of ibuprofen
1200-3200 mg/day in divided doses
What NSAIDs work on both the lipooxygenase and cyclooxygenase pathways
-ketoprofen and diclofenac
What is the difference between Cataflam and Voltaren
-Cataflam is diclofenac potassium and has in immediate release
-Voltaren is diclofenac sodium and has a delayed release
What are the only pro-drugs for NSAIDs
nabumetone and sulindac
What is the only nonacidic NSAID
nabumetone
Which NSAIDs have fewer pulmonary problems
ketoprofen and diclofenac
What are the 6 classification types of NSAIDs
-Salicylic acid derivatives
-Propionic acid
-Acetic acid
-Fenamates
-Enolic/-oxicams
-Cox2 inhibitors
What are the salicylic acid medications (4)
-ASA
-diflunisal
-salsalate
-Trilisate
What are the propionic acid medications (5)
-flurbiprofen
-ibuprofen
-ketoprofen
-naproxen
-oxaprozin
What are the acetic acid medications (7)
-diclofenac
-etodolac
-indomethacin
-ketorolac
-nabumetone
-sulindac
-tolmetin
Enolic acid/ oxicams (2)
meloxicam and piroxicam
Cox-2 inhibitors
celecoxib