Drugs And Translocations

Question 1

(8;14)

Answer 1

Burkitt’s lympoma

Question 2

(8;21)

Answer 2

AML

Question 3

(9;22)

Answer 3

CML

Question 4

(11;14)

Answer 4

Mantle Cell Lymphoma

Question 5

(12;21)

Answer 5

ALL

Question 6

(14;18)

Answer 6

Follicular Lympoma

Question 7

(15;17)

Answer 7

APL

Question 8

Rituximab

Answer 8

CLL/SLL (works against CD20)

Question 9

To avoid tumor lysis syndrome (2)

Answer 9

1. Aggressive IV fluids

2. Allopurinol

Question 10

How to treat tumor lysis syndrome

Answer 10

Treat each electrolyte abnormalities (high K/P/urea + low Ca)

Question 11

ATRA

Answer 11

APL

Question 12

How to treat congestive splenomegaly secondary to Cirrhosis

Answer 12

Reduce portal vein congestion via shunt

Question 13

DDAVP / desmopressin

Answer 13

Von Willebrand Disease

Question 14

How to treat major bleeding in vWF disease

Answer 14

VWF: recombinant or plasma-derived

Question 15

Emicizumab

Answer 15

Hemophilia A

Question 16

Heparin inhibits which four factors?

Answer 16

2, 9, 10, 11

Question 17

Xarelto, rivaroxaban, apixaban, endoxaban

Answer 17

Factor Xa inhibitors

Question 18

Dabigatran

Answer 18

Direct thrombin inhibitor

Question 19

Warfarin: blocks what four factors

Answer 19

(Vitamin K dependent factors) 2, 7, 9, 10

Question 20

Hydroxyurea

Answer 20

Sickle cell anemia

Question 21

Epoetin alfa

Answer 21

Anemia due to: CKD, cancer, HIV treatment

Question 22

Eculizumab

Answer 22

PNH and HUS

Question 23

Filgrastim, sargramostim, plerixafor

Answer 23

Severe neutropenia

Question 24

Oprelvekin, romiplostim, eltrombopag

Answer 24

Thrombocytopenia

Question 25

Drug for CLL/SLL

Answer 25

Rituximab

Question 26

Drug for APL

Answer 26

ATRA

Question 27

Drug for Von Willebrand Disease

Answer 27

DDAVP/desmopressin

Question 28

Drug for hemophilia A

Answer 28

Emicizumab

Question 29

Drug for anemia due to: CKD, CA, or HIV treatment

Answer 29

Epoetin Alfa

Question 30

Drug for PNH and HUS

Answer 30

Eculizumab

Question 31

Three drugs for severe neutropenia

Answer 31

1. Filgrastim
2. Sargramostim
3. Plerixafor

Question 32

Three drugs for thrombocytopenia

Answer 32

1. Oprelvekin
2. Romiplostim
3. Eltrombopag

Question 33

Drug for CML

Answer 33

Imatinib (Gleevec)