Drugs And Receptors Flashcards
Mu1 receptors have analgesia:
-where in relation to spine?
-main side effects from this receptor?
-spinal and supra spinal
- urinary retention
- bradycardia
Mu2 receptors responsible for what side effects?
- hypo ventilation
- constipation
- physical dependence
Which opioid receptor responsible for euphoria?
-dysphoria?
- Mu1
- Delta & sigma
Opioid receptor(s) causing:
- hypoventilation
- constipation
- physical dependence
Mu2 & Delta
Opioid receptors causing urinary retention?
Mu1 & delta
M & D…..MY 1 DICK can’t pee
Two opioid receptors causing dysphoria?
Delta & sigma
DIS phoria….Delta, Sigma
Opioid receptor that ONLY acts spinally (not supra spinal)
Mu2
Which opioid receptor causes DIURESIS?
Kappa only
Kant put a Kap on it….just keeps going
Opioid receptor causing bradycardia?
Tachycardia?
- mu1 = BRADY
- sigma = TACHY
Which opioid may cause tachycardia D/t it’s atropine-like structure?
Meperidine
What’s also released along with meperidine admin that can cause BRONCHOspasm?
Histamine
Tv with opioids?
INCREASED
RR w/ opioids?
decreased
BAD pulm SE of opiods admin?
chest wall rigidity
Renal failure probs with opioids?
toxicity risk d/t toxic metabolites
ICP with opioids?
DECREASE
CBF with opioids?
DECREASE
CMRO2 with opioids?
DECREASE
careful with elevated ICP patient giving them opioids bc why?
can decrease it, and want to maintain CPP
opioids inhibit what sort of EEG?
isoelectric
why n/v with opioids
medulla chemorector zone stimulation
two gastro SE of opioids
constipation
biliary colic
NO TOLERANCE TO WHICH TWO SE OF opioids?
- CONSTIPATION
- miosis
which opioids receptor gives NO analgesia?
sigma
opioids better at providing what response vs volatiles?
better at mediating stress response
which opiate has the fastest onset of action? (fentanyl-type opiates)
alfentanil (d/t pKa) greater portion of unionized fraction of alfentanil
(pKa of 6.8….ONLY one less than physiologic pKa)
nitrous + O2 mixture relates in density HOW to regular O2?
more dense than plain O2
Efficacy vs potency? And what does GRAPH look like?
Efficacy is FINAL total endpoint on graph of drug (how tall sigmoid height is)
POTENCY is how little u can give FOR that max effect (more left shift is more potent)
Efficacy vs potency? And what does GRAPH look like?
Efficacy is FINAL total endpoint on graph of drug (how tall sigmoid height is)
POTENCY is how little u can give FOR that max effect (more left shift is more potent)
Which of the anesthesia gases we use has the HIGHEST vapor pressure?
Nitrous Oxide - 38,000!!!
Desflurane - 660
Vapor pressure is proportional to which part of gas equations?
TEMPERATURE
