Drugs And Receptors

Question 1

Mu1 receptors have analgesia:
-where in relation to spine?

-main side effects from this receptor?

Answer 1

-spinal and supra spinal

• urinary retention
• bradycardia

Question 2

Mu2 receptors responsible for what side effects?

Answer 2

• hypo ventilation
• constipation
• physical dependence

Question 3

Which opioid receptor responsible for euphoria?

-dysphoria?

Answer 3

• Mu1

- Delta & sigma

Question 4

Opioid receptor(s) causing:

• hypoventilation
• constipation
• physical dependence

Answer 4

Mu2 & Delta

Question 5

Opioid receptors causing urinary retention?

Answer 5

Mu1 & delta

M & D…..MY 1 DICK can’t pee

Question 6

Two opioid receptors causing dysphoria?

Answer 6

Delta & sigma

DIS phoria….Delta, Sigma

Question 7

Opioid receptor that ONLY acts spinally (not supra spinal)

Answer 7

Mu2

Question 8

Which opioid receptor causes DIURESIS?

Answer 8

Kappa only

Kant put a Kap on it….just keeps going

Question 9

Opioid receptor causing bradycardia?

Tachycardia?

Answer 9

• mu1 = BRADY

- sigma = TACHY

Question 10

Which opioid may cause tachycardia D/t it’s atropine-like structure?

Answer 10

Meperidine

Question 11

What’s also released along with meperidine admin that can cause BRONCHOspasm?

Answer 11

Histamine

Question 12

Tv with opioids?

Answer 12

INCREASED

Question 13

RR w/ opioids?

Answer 13

decreased

Question 14

BAD pulm SE of opiods admin?

Answer 14

chest wall rigidity

Question 15

Renal failure probs with opioids?

Answer 15

toxicity risk d/t toxic metabolites

Question 16

ICP with opioids?

Answer 16

DECREASE

Question 17

CBF with opioids?

Answer 17

DECREASE

Question 18

CMRO2 with opioids?

Answer 18

DECREASE

Question 19

careful with elevated ICP patient giving them opioids bc why?

Answer 19

can decrease it, and want to maintain CPP

Question 20

opioids inhibit what sort of EEG?

Answer 20

isoelectric

Question 21

why n/v with opioids

Answer 21

medulla chemorector zone stimulation

Question 22

two gastro SE of opioids

Answer 22

constipation

biliary colic

Question 23

NO TOLERANCE TO WHICH TWO SE OF opioids?

Answer 23

• CONSTIPATION

- miosis

Question 24

which opioids receptor gives NO analgesia?

Answer 24

sigma

Question 25

opioids better at providing what response vs volatiles?

Answer 25

better at mediating stress response

Question 26

which opiate has the fastest onset of action? (fentanyl-type opiates)

Answer 26

alfentanil (d/t pKa) greater portion of unionized fraction of alfentanil

(pKa of 6.8….ONLY one less than physiologic pKa)

Question 27

nitrous + O2 mixture relates in density HOW to regular O2?

Answer 27

more dense than plain O2

Question 28

Efficacy vs potency? And what does GRAPH look like?

Answer 28

Efficacy is FINAL total endpoint on graph of drug (how tall sigmoid height is)

POTENCY is how little u can give FOR that max effect (more left shift is more potent)

Question 29

Efficacy vs potency? And what does GRAPH look like?

Answer 29

Efficacy is FINAL total endpoint on graph of drug (how tall sigmoid height is)

POTENCY is how little u can give FOR that max effect (more left shift is more potent)

Question 30

Which of the anesthesia gases we use has the HIGHEST vapor pressure?

Answer 30

Nitrous Oxide - 38,000!!!

Desflurane - 660

Question 31

Vapor pressure is proportional to which part of gas equations?

Answer 31

TEMPERATURE