Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm II > Drugs all > Flashcards

Drugs all Flashcards

1
Q

4 Hemostatic Agents

A

1) Vitamin K
2) Protamine Sulfate
3) Epsilon Aminocaproic Acid (EACA)/Tranexmil Acid (TXA)
4) Desmopressin Acetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Protamine sulfate is DOC for…

A

Tx of hemorrhage secondary to Heparin OD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Anti fibrinolytic agent

A

Epsilon Aminocaproic Acid (EACA)/Tranexmil Acid (TXA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Desmopressin Acetate is DOC for…

A

Tx bleeding due to VWD dz and tx central diabetes insipidus
(+ asparin tox in dogs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Desmopressin MOA

A

Cause dose dependent increase in plasma factor VIII and plasminogen factor (supports primary hemostasis -> platelet fxn)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

2 Antithrombotic drugs

A

1) Aspirin
2) Clopidogrel Bisulfate (Plavix)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

[High or Low] aspirin dose is preferred when using it as an antithrombotic

A

Low dose preferred because high dose can cause increase in platelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Clopidogrel MOA

A

Reduce platelet aggregation by selectively inhibiting the ADP receptor on platelet surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

4 Anticoagulant drugs

A

1) Unfractionated Heparin
2) Low molecular weight heparin
3) Warfarin Sodium
4) Rivaroxaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Is risk of bleeding higher for anticoagulants or antithrombotics?

A

Anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What drug do you need to monitor aPTT

A

Unfractionated Heparain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Unfractionated heparin + Low molecular weight heparin MOA

A

Binds to antithrombin III to inactivate coagulation factor Xa and prevents the conversion of prothrombin to thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Warfarin Sodium MOA (imp)

A

Inhibit Vitamin K Epoxide Reductase, which interferes with action of Vit K bc Vit K synthesizes coag factors II, VII, IX, X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What drug do you have to monitor PT clotting time

A

Warfarin Sodium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What drug is a direct factor Xa inhibitor

A

Rivaroxaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Of the two thrombolytics, which is fibrin clot SPECIFIC?

A

tissue plasminogen activator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2 thrombolytic drugs + MOA + Precaution

A

1) Streptokinase/Urokinase
2) Tissue Plasminogen Activator (t-PA)
MOA: activate plasminogen to breakdown existing clots -> thrombolysis
Precaution: life threatening hemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Three (behavior modifying) drugs that increase serotonin levels in the brain

A

Buspirone, Fluoxetine, Trazadone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Drug to tx feather plucking in birds

A

Clomipramide (TCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Fluoxetine

A

SRRI, inhibit neuronal reputake of serotonin and upregulate GABA receptors
Use: separation anxiety, dominance agression, acral lick granuloma….

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Reserpine

A

Indirect acting sympatholytic
MOA: blocks NE uptake into vesicles to reduce storage and release of NE
Long acting tranquilizing agent in horses (ie long term stall rest)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Clomipramide precaution

A

Narrow therapeutic index; cats more sensitive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Buspirone

A

Partial serotonin agonist
MOA: increase serotonin levles in brain
DOC: cats for urinary marking, spraying behaviors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Difference between first and second generation H1 Antagonists

A

H1: cross BBB, drowsy
H2: non-drowsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

H1 (4)

A

1) Proinflammatory
2) Bronchoconstriction
3) Vasodilation
4) Mediate signs of urticarial + pruritis

18
Q

H2 (2)

A

1) Increase gastric acid secretion
2) Vascular SM relaxation

19
Q

Consideration for Lokivetmab

A

USDA biological agent (not FDA approved drug)

20
Q

Oclacitinib

A

Apoquel
JAK-1 and 3 inhibitor
Inhibits pro-inflam cytokines
Inhibits IL-31
Tx allergic dermatopathy in dogs

21
Q

Lokivetmab MOA

A

Contains canonized monoclonal Abs shown to neutralize IL-31
Side effect: persistent ABs may reduce effects

22
Q

DOC and MOA of drug to tx long term feline hyperthyroidism

A

Methimazole
Inhibit thyroid hormone synthesis (reversible)
Stop if: facial excoriation

23
Q

Hyperthyroid tx that is irreversible

A

Radioactive Iodine (+ tx functional extra-thyroid tissue

24
Q

Tx for acute vs chronic Hypocalcemia

A

Acute: calcium gluconate
Chronic: Calcitriol (Vit D)

25
Q

Pamidronate Disodium

A

MOA: inhibit bone resorption (to tx HyperCa)
Slow onset of action, NOT for emergency tx HyperCa
Main use: severe hyperCa usually due to malignancy (ie osteosarcoma)

26
Q

Drug for medical management of insulinoma (chronic hypoglycemia) in small animals

A

Diazoxide (not emergency drug)
Oral formulation

27
Q

Tx for hypoglycemic crisis

A

50% dextrose
DILUTE w crystalloid

28
Q

Which is the only type of insulin that can be given IV

A

short acting: regular/lispro

29
Q

DOC diabetes mellitus

A

Insulin

30
Q

Long acting insulin drugs (3) + Which has the highest potency in dogs?

A

Glargine
Detemir (4x potency in dogs)
Protamine Zinc

31
Q

2 oral drugs to tx diabetes mellitus + MOA

A

Bexaglifozin + Velagliflozin
MOA: SGLT2 inhibitor

32
Q

Glucocorticoid dose to tx Addisons

A

0.2-0.3 mg/kg/day

33
Q

Glucocorticoid dose for anti inflammatory

A

0.5-1 mg/kg/day

34
Q

Glucocorticoid dose for immunsupressive therapy

A

2-4 mg/kg/day

35
Q

2 drugs that inhibit glucocorticoid production (to tx cushings), and which is more common?

A

Trilostaine (more common) + Ketoconazole

36
Q

What enzyme does Trilostane inhibit, and is it reversible or irreversible?

A

3b-hydroxysteroid dehydrogenase; reversible

37
Q

Pergolide

A

Dopamine agonist
PPID in horses

38
Q

2 mineralcorticoids and what should you monitor when using?

A

DOCP + Fludrocortisone
Monitor K/Na

39
Q

DOC addisons

A

DOCP + Fludrocortisone

40
Q

Acetaminophen MOA

A

Does not inhibit COX, but interferes with conversion of endoperodixases to other prostaglandins

41
Q

Drug for feline osteothritis and route of administration

A

Frunevetmab (solensia); once monthly injectable

42
Q

Amantadine classification and MOA

A

Antiviral with NMDA receptor antagonism (analgesic effects)

43
Q

Large animal triple dip

A

Guaifenesin, xylazine, ketamine

44
Q

Kitty magic (anesthesia induction)

A

Ketamine, Dexmedetomidine, Buprenorophine

45
Q

Adjunct anesthesia (FLK and MLK)

A

Fentanyl, lidocaine, ketamine
Morphine, lidocaine, ketamine

46
Q

Which non-barbituate induction agent is best to use for patients with CV dz

A

Etomidate (less severe CV effects than other IV anesthetics)

47
Q

Rank respiratory and CV depression of non-barbituates most to least

A

Propofol>Alfaxalone>Etomidate

48
Q

3 non barbituate drugs and MOA

A

Propofol, Alfaxalone, Etomidate
GABA agonist

49
Q

DOC for tetatnus, intoxication that causes tremors, and use of wrong flea/tick product

A

Methocarbamol

50
Q

Drug for medical management of insulinoma vs acute treatment for insulinoma

A

Management: Diazoxide
Acute tx: Glucagon

51
Q

Dopamine causes at:
1) Low dose
2) Low-medium dose
3) Medium dose
4) High dose

A

Low dose: D receptors -> renal vasodilation
Low-medium dose: B1 -> Positive inotrope
Medium dose: B1 -> Positive chronotrope
High dose: A1 -> Vasoconstriction

52
Q
A

Pharm II (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions