Drugs Flashcards
1
Q
Salbutamol
A
SABA - short term bronchodilation - agonises B2 receptors COPD + Asthma 5mg per 15mins in acute asthma attack Over dose = Beta 1 activation + CO
2
Q
Salmeterol/ formoterol
A
LABA - long acting bronchodilation - agonises B2 3rd line asthma COPD + LAMA
3
Q
Beclometasone Diproprinate
A
ICS - Prevents inflammation - promotes anti inflammation - Lipophilic 2nd line asthma eosinophilic COPD Immune suppression - HIGH WBC count
4
Q
Budesonide/ fluticasone
A
ICS
5
Q
Prednisolone
A
Oral corticosteroid
- 2 week max usage
side effects
Pneumonia in COPD
6
Q
Theophylline
A
Methyl xanthine - Inhibits Phosphodiesterase - Greater PKA activity 4th line asthma treatment - narrow therapeutic window
7
Q
Montelukast/ zafirlukast
A
Leukotriene Receptor Antagonists - Block leukotriene binding - NSAIDs asthma - Prevents oedema + mucous hypersecretion 3rd line asthma treatment
8
Q
Sodium Chromoglicate
A
Chromone
mast cell stabiliser
prevents degranulation
4th line
9
Q
Omalizumab
A
Anti IgE
- Prevents mast cell response
4th line
10
Q
mepolizumab/ benralizumab
A
Anti Il - 5
Prevents eosinophil influx
11
Q
Dupilumab
A
Anti IL 4 alpha
- block IL-4 + IL13 binding
- Prevents B cell activation + goblet cell hyper secretion
12
Q
Ipratropium
A
SAMA
- Antagonised M3 receptors
- prevents bronchoconstriction
- 0.5mg every 15 mins in acute asthma attack
13
Q
Tiotropium
A
LAMA
- long acting M3 antagonist
1st line COPD + LABA
14
Q
Rifampicin
A
TB treatment
Jaundice/ acute porphyria/ hepatitis/ sickness/ thrombocytopenia/ leucopenia
15
Q
Isoniazid
A
TB treatment
Acute porphyria/ hepatitis
