Drugs

Question 1

Humira

Answer 1

humanized monoclonal ab to TNF-alpha (for arthritis)

Question 2

Embrel

Answer 2

soluble monoclonal ab to TNF-alpha (for arthritis)

Question 3

Rituximab

Answer 3

wipes out CD20 B cells

Question 4

Rhogamma

Answer 4

immune globulin to Rh factor –> Prevents hemolytic disease of the newborn by binding up the Rh that the Rh- mother was exposed to so that she does not create anti-Rh antibodies and her subsequent pregnancy is ok if baby is Rh+

Question 5

Tysabri

Answer 5

monoclonal ab blocks adhesion molecules on T cells therefore prevents their ability to efflux (extravasate) to brain (MS) or GI tract (Crohn’s)

Question 6

Tofacitinib

Answer 6

Jak3 inhibitor for RA

Question 7

Ruxolitinib

Answer 7

Jak1/2 inhibitor

Question 8

RhoGam

Answer 8

antibodies to D antigen serves to prevent antibody induction in mom; if this is done again at 28 weeks of gestation it reduces risk even more

Question 9

Abatacept

Answer 9

form of soluble CTLA-4 that will bind CD80 and CD86 and block costimulation, therefore is anti-inflammatory.

used in Rheumatoid Arthritis patients

Question 10

Orencia

Answer 10

commercial name for Abatacept

form of soluble CTLA-4 that will bind CD80 and CD86 and block costimulation, therefore is anti-inflammatory.

used in Rheumatoid Arthritis patients

Question 11

anti-CTLA-4 antibodies

Answer 11

unleash T cell attack on Tumors

Question 12

Remicade

Answer 12

anti-TNF-a Ab

Question 13

Anti-BLys

Answer 13

to block B cell survival and differentiation in plasma cells in SLE

Question 14

Azathioprine

Answer 14

first immunosuppressant used in organ transplantation; inhibits purine synthesis ; block T cell proliferation

Question 15

Methotrexate

Answer 15

block T cell proliferation

Question 16

Cyclophosphamide

Answer 16

block T cell proliferation

Question 17

Mycophenolate mofetil

Answer 17

block T cell proliferation by preventing production of purines andpyrimindines; broad affect

Question 18

Sirolimus

Answer 18

block IL2-R

Question 19

Rapamycin

Answer 19

block IL2-R

Question 20

cyclosporin-a

Answer 20

block IL2 production by inhibiting the activation of

Question 21

Cross-presentation of exogenous Ags to CD8 T cells

is what kind of recognition

Answer 21

indirect recognition

Question 22

omalizumab

Answer 22

anti-IgE antibody

Question 23

tx for AMR

Answer 23

plasmapheresis, high dose pulses of glucocorticoids, IV-Ig and antiproliferative agents;
Rituximab (anti-CD20 depletes B cells)

Question 24

prednisone

Answer 24

corticosteroid that stops activation of immune system

Question 25

dexamethasone

Answer 25

corticosteroid that stops activation of immune system

Question 26

thalidomide

Answer 26

useful in managing skin manifestations of lupus

Question 27

azathioprine

Answer 27

antimetabolite that interferes with nucleic acid metabolism; metabolized to mercaptopurine and is toxic

Question 28

chromolyn sodium

Answer 28

tx for type I hypersensitivity

Question 29

theophylline

Answer 29

tx for type I hypersensitivity

Question 30

Plaquenil

Answer 30

hydroxychloroquine for SLE; incr acidity of lysosomes and thereby prevents lysosomal action

Question 31

Belimumab

Answer 31

human IgG1 lambda monoclonal antibody that inhibits the binding of soluble human B lymphocyte stimulator protein

Question 32

infliximab

Answer 32

target TNF alpha to reduce inflammation in RA

Question 33

fingolimod

Answer 33

FYT720 sphingosine analog that inhibits lymphocyte exit from lymph node; tx for MS

Question 34

FYT720

Answer 34

fingolimod; sphingosine analog

Question 35

yervoy

Answer 35

blocks CTLA4 therefore promotes T cell differentiation

Question 36

what does Pcr detect?

Answer 36

whether a virus is present

Question 37

what does immune or western blotting detect

Answer 37

presence of antibodies