Drugs Flashcards
Humira
humanized monoclonal ab to TNF-alpha (for arthritis)
Embrel
soluble monoclonal ab to TNF-alpha (for arthritis)
Rituximab
wipes out CD20 B cells
Rhogamma
immune globulin to Rh factor –> Prevents hemolytic disease of the newborn by binding up the Rh that the Rh- mother was exposed to so that she does not create anti-Rh antibodies and her subsequent pregnancy is ok if baby is Rh+
Tysabri
monoclonal ab blocks adhesion molecules on T cells therefore prevents their ability to efflux (extravasate) to brain (MS) or GI tract (Crohn’s)
Tofacitinib
Jak3 inhibitor for RA
Ruxolitinib
Jak1/2 inhibitor
RhoGam
antibodies to D antigen serves to prevent antibody induction in mom; if this is done again at 28 weeks of gestation it reduces risk even more
Abatacept
form of soluble CTLA-4 that will bind CD80 and CD86 and block costimulation, therefore is anti-inflammatory.
used in Rheumatoid Arthritis patients
Orencia
commercial name for Abatacept
form of soluble CTLA-4 that will bind CD80 and CD86 and block costimulation, therefore is anti-inflammatory.
used in Rheumatoid Arthritis patients
anti-CTLA-4 antibodies
unleash T cell attack on Tumors
Remicade
anti-TNF-a Ab
Anti-BLys
to block B cell survival and differentiation in plasma cells in SLE
Azathioprine
first immunosuppressant used in organ transplantation; inhibits purine synthesis ; block T cell proliferation
Methotrexate
block T cell proliferation
Cyclophosphamide
block T cell proliferation
Mycophenolate mofetil
block T cell proliferation by preventing production of purines andpyrimindines; broad affect
Sirolimus
block IL2-R
Rapamycin
block IL2-R
cyclosporin-a
block IL2 production by inhibiting the activation of
Cross-presentation of exogenous Ags to CD8 T cells
is what kind of recognition
indirect recognition
omalizumab
anti-IgE antibody
tx for AMR
plasmapheresis, high dose pulses of glucocorticoids, IV-Ig and antiproliferative agents;
Rituximab (anti-CD20 depletes B cells)
prednisone
corticosteroid that stops activation of immune system
dexamethasone
corticosteroid that stops activation of immune system
thalidomide
useful in managing skin manifestations of lupus
azathioprine
antimetabolite that interferes with nucleic acid metabolism; metabolized to mercaptopurine and is toxic
chromolyn sodium
tx for type I hypersensitivity
theophylline
tx for type I hypersensitivity
Plaquenil
hydroxychloroquine for SLE; incr acidity of lysosomes and thereby prevents lysosomal action
Belimumab
human IgG1 lambda monoclonal antibody that inhibits the binding of soluble human B lymphocyte stimulator protein
infliximab
target TNF alpha to reduce inflammation in RA
fingolimod
FYT720 sphingosine analog that inhibits lymphocyte exit from lymph node; tx for MS
FYT720
fingolimod; sphingosine analog
yervoy
blocks CTLA4 therefore promotes T cell differentiation
what does Pcr detect?
whether a virus is present
what does immune or western blotting detect
presence of antibodies