Drugs Flashcards
only 5 for this one
Name two bronchodilators
Salbutamol/salmeterol
Xanthine (theophylline)
What is the mechanism of action of salbutamol
Beta 2 receptor agonist , cAMP increases Ca2+ decreases
What is the difference in Salbutamol/salmeterol
Salbutamol = short acting - as needed Salmetrol = long acting - twice daily
full mechanism of action for salbutamol
Beta 2 adrenergic receptor, increases adenylate cyclase, thus increases cAMP, thus intracellular Ca 2+ is reduced leading to bronchodilator and inhibits the phosphorylation of myosin
mechanism of action of xanthine (theophylline)
Inhibits phosphodiesterase which then increases cAMP production which causes bronchodilation
What does Ipratropium do
Antagonists at Ach receptors at the cholinergic nerves in the parasympathetic nervous system thus fewer muscarinic receptors (Ach receptors) activated thus less mucus is secreted
What does leukotriene prevent
bronchospasm
mechanism of action of leukotrine
Prevents exercise induced asthma and acts as a leyukotrine receptor antagonist thus no C4 or D4 (leukotrines) are smooth muscle cell contractors thus prevents actions of brohchial spasmogens
what is the blue inhaler and the brown one
blue is salbutamol/salmeterol and brown is glucocorticoid steroid
What does a glucocorticoid do
immune supression
mechanism of action of a glucocorticoid
Decreases cytokines (Th2 which recruit and activated eosinophils) . Decreases influx of eosinophils and blocks arachidonic pathway and represses IL-3 which regulates mast cell production.
