Agonists too Antagonists Flashcards
to get a great deal
What is EC50
parameter 50% of the maximum response
What is Non - competitive antagonism
Antagonist bings at a different site to the agonist
What does an agonist favour in terms of active receptor and non-active receptor
Active receptor
Do an antagonist affect the overall equilibrium
no brother
Does the receptor still have the same chance of spontaneously activating with the agonist-bound
yes bro
What is a partial agonist
It doesn’t select between an active state and inactive state like an agonist
What is the difference in response and full and partial agonists
a partial agonist will not get the same response as a full agonists
What is an inverse agonist
Binds much tighter to an inactive state rather than an active state
What is potency
The concentration of a drug it takes to cause a particular effect eg EC50
What is affinity
How tightly something binds
What is efficacy
The magnitude of the effect a drug can achieve at saturation
In terms of efficacy, what does a full, partial, competitive and inverse agonist have
Full = maximun efficacy partial = partial efficacy Competitive = 0 inverse = negative and reduce baseline affects of receptor
