Drugs Flashcards
What are the non-depolarising blockers?
- Atracurium
- Mivacurium
- Pancuronium
- Vecuronium
- Rocuronium
Non depolarising blocker(s) with medium onset and medium duration
- Vecuronium
* Atracurium
Non depolarising blocker(s) fast onset and short duration
• Mivacurium
Non depolarising blocker(s) with medium onset and a long duration
• Pancuronium
Non depolarising blocker(s) with a fast onset and medium duration
• Rocuronium
Pancuronium
- Medium onset
- Long duration
- Tachycardia
- Hepatic metabolism
- Non depolarising blocker - antagonist
Vecuronium
- Medium onset
- Medium duration
- Few side effects
- Hepatic metabolism
- Non depolarising blocker - antagonist
Rocuronium
- Fast onset
- Medium duration
- Tachycardia
- Unchanged in bile/urine
- Non-Depolarising blocker - antagonist
Atracurium
- Medium onset
- Medium duration
- Hypertension / bronchospasm
- Ester hydrolysis/ Hoffman elimination
- Non-depolarising blocker - antagonist
Mivacurium
- Fast onset
- Short duration
- Hypertension / Bronchospasm
- Plasma cholinesterase
- Non depolarising blocker - antagonist
Suxamethonium
- Fast onset
- Short acting
- Bradycardia
- malignant Hypothermia
- Post operative Myalgia
- Increases intraocular pressure
- Cardiac dysrhythmia
- Depolarising blocker -agonist
Medium acting anticholinesterase drug(s)
• Neostigmine
• Pyridostigmine
(Quaternary amines)
Long acting anticholinesterase drug(s)
• Dyflos
• Parathon
(organophosphates)
Neostigmine
- Medium acting
- Anticholinesterase
- Quaternary amine
- SLUDGE, bradycardia, hypotension, pupil constriction, bronchoconstriction
Pyridostigmine
- Medium acting
- Anticholinesterase
- Quaternary amine
- SLUDGE, Bradycardia, Bronchoconstrion, Pupil constriction (miosis), Hypotension
Dyflos
- Long acting anticholinesterase
- organophosphate
- SLUDGE, Bradycardia, Hypotension, miosis, Bronchoconstriction
- Potentially irreversible
Parathion
- Long acting anticholesterase
- Organophosphate
- SLUDGE, Bradycardia, Hypotension, Miosis, Bronchoconstriction
- Potentially irreversible
Non-selective muscarinic agonists
- Pilocarpine
* Bethanechol
Non-selective muscarine antagonists
- Atropine
- Glycopyrronium
- Hyoscine Hydobromide
- Hyoscine Butylbromide
- Ipratropium
- Tropicamide
Which non selective muscarinic antagonists affect the CNS?
- Atropine
* Hyoscine hydrobromide
Which non-selective muscarinic antagonists cannot cross the blood brain barrier?
- Glycopyrronium
- Hyoscine butyl bromide
- Ipratropium
Pilocarpine
- Non-selective muscarinic agonist
- Constricts pupils
- Decreases intraocular pressure (Treats Glaucoma)
- Increases salivation (Xerostomia)
Bethanechol
- Non-selective muscarinic agonist
- Increases smooth muscle tone
- Treats bladder hypotonia
Atropine
- Non-Selective muscarinic antagonist
- Treats bradycardia
- Treats anticholinesterase poisoning
- Adjunct for anaesthesia
