Drugs Flashcards
What is the MOA of minoxidil?
What is it used for? (2)
Minoxidil
- Direct arteriolar vasodilator
- Male pattern baldness, severe HTN
What is the MOA of sildenafil?
Clinical use (2)
Side effects (5)
Sildenafil
- PDE-5 inhibitor -> increased cGMP -> vasodilation
- Treats erectile dysfunction, pulmonary HTN
- Hot & sweaty, headache, hypotension, heartburn, hue changes (cyanopia)
What is the MOA of flutamide?
Use?
Flutamide
- competitive inhibitor at androgen receptors
- used to treat prostate cancer
MOA of danazol
Use (2)
Danazol
- Partial agonist at androgen receptors
- Treats endometriosis and hereditary angioedema
What are tocolytics?
Give 3 examples
Tocolytics
- Medications that relax the uterus
- Terbutaline (beta2 agonist)
- Nifedipine (CCB)
- Indomethacin (NSAID)
Why do we administer steroids to women in preterm labor?
What drug allows us to give steroids prior to birth?
Steroids increase fetal lung maturity & surfactant production
Tocolytics give us enough time to administer steroids
What is the mechanism of mifepristone?
Use?
Mifepristone
- Competitive inhibitor of progesterone receptor
- Used together with misoprostol to terminate pregnancy
What is the mechanism and use of ulipristal?
- Ulipristal is a competitive progesterone blocker that delays ovulation
- Used for emergency contraception
What is the most effective form of emergency contraception?
Copper IUD
What drug is given in the case of postpartum hemorrhage?
Why?
Oxytocin
(promotes contraction of smooth muscle)
Which GPCR causes relaxation/dilation of cervix & uterus?
What GPCR causes contraction?
- Gq - contraction
- Gs - relaxation & dilation
What signaling molecule class is responsible for cervical dilation?
PG’s
Uterine contraction is stimulated by ___’s and ____ (hormone) via opening of ___________
Uterine contraction is stimulated by PG’s and oxytocin via opening of L-type calcium channels
