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Immuno > Drugs > Flashcards

Drugs Flashcards

1
Q

4 anti tumor drugs

A

Cetuximab
Erlotinib
Trastuzumab
Bevacizumab

“Cheating Boys Eat Trash”

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2
Q

Cetuximab MOA

A

Binds EGF-R

Initiates ADCC

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3
Q

Cetuximab AE

A

Infusion site rxn (brochospasm, HoTN)
Interstitial lung dz
Rash

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4
Q

Erlotinib MOA

A

Tyrosine Kinase inhibitor for mutant EGF-R

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5
Q

Erlotinib AE

A 
Corneal Damage
Interstitial Lung Dz
Liver Tox
Diarrhea
Rash (Steven Johnson)
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6
Q

Trastuzumab MOA

A

HER-2 -R blocker

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7
Q

Trastuzumab AE

A

Cardiomyopathy

Injection site Rxn

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8
Q

Bevacizumab MOA

A

Inactivates VEGF

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9
Q

Bevacizumab AE

A

Wound rupture
Bleeding
GI perf

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10
Q

Calcineurin inhibitor examples

A

Tacrolimus

Cyclosporine

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11
Q

Drugs that decrease T cell activation for immunosuppression

A

Tacrolimus
Cyclosporine
Belatacept
Muromumab

“They Can’t Break Me”

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12
Q

Calcineurin inhib indications

A

RA

Transplant rejection prophylaxis

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13
Q

Calcineurin inhibitor AE

A

Hyper-K
Nephrotox
HTN

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14
Q

Belatacept MOA

A

“Pretend CTLA”

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15
Q

Belatacept indic

A

Transplant rejection prophylaxis

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16
Q

Muromumab indic

A

T1 DM

Transplant rejection prophylaxis

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17
Q

Muromumab AE

A

cytokine induced syndrome (chill, fevers, dyspnea)

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18
Q

Rituximab MOA

A

CD20 antibody –> killed by ADCC/complement
Thus dec B cell activation

immunosuppressive drug

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19
Q

Rituximab Indic

A 
B-cell lymphoma
MS
Systemic autoimmune Complex Dz
-SLE (lupus)
-RA
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20
Q

Rituximab AE

A

Rash
PML
HBV
Pyogenic bact infect

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21
Q

Anticytokine drugs (Immunosuppresion)

A 
"Attack the Evil A.I"
Infliximab
Adalimumab
Etanercept
Anakinra
Tocilizumab
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22
Q

Which anticytokine drugs dec TNF via antibodies>

A

Infliximab

Adaliumab

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23
Q

Which anticytokine drug dec TNF via TNF-R

A

Etancercept

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24
Q

Indic of TNF dec drugs

A

RA
Psoriatic arthritis
Crohn’s (inflix & adal only)

25
Q

AE of TNF dec drugs

A

Inc risk of TB, HepB
GI effects

CI: HF

26
Q

ANakinra MOA

A

Dec IL-1

27
Q

ANakinra INdic

A

RA

Hereditary fever syndrome (FCAS)

28
Q

Anakinra AE

A

INjection site rxn

29
Q

Tocilizumab MOA

A

Dec IL-6

30
Q

Tocilizumab Indic

A

RA

31
Q

Tocilizumab AE

A

Inc Infections
MOnitor LFTs
Hyperlipidemia

32
Q

Immunosuppressive drug that is an Antiintegrin & blocks VLA-4

A

Natalizumab

33
Q

Natalizumab Indic

A

Inflammatory dz:

  • MS
  • IBD
  • RA
34
Q

Natalizumab AE

A

PML

Monitor LFTs

35
Q

Prednisone Indic

A 
Dec organ transplant rejection
Type IV-Th1 hypersensitivity
Exacerbation of chronic asthma (Type IV-Th2)
RA
SLE (lupus)
Osteoarthritis
Gouty arthritis
36
Q

Prednisone AE

A 
OBesity
dyslipidemia
Ostoporosis
Skin atrophy
GI bleed

CI: TB, systemic fungal infection

37
Q

Which therapies target IgE response?

A

Allergen spicific immunotherapy (SIT)

Omalizumab

38
Q

Allergen SIT MOA

A

Sub q injections of gradually inc antigens until Treg response through IL-10

39
Q

Allergen SIT indic

A

Allergic rhinitis

Allergic asthma

40
Q

Allergen SIT AE, CI

A

AE: Anaphylaxis
CI: Severe asthma, CVD

41
Q

Omalizumab MOA

A

Anti-IgE antibody (Fc position)

42
Q

Omalizumab Indic

A

Prophylaxis/control of moderate –> severe allergic asthma

43
Q

Omalizumab AE

A

Injection site rxn

Anaphylaxis

44
Q

Which therapies target mast cell degranulation

A

Mepolizumab
Chlorpherniamine
Fexofenadine
Montelukast

45
Q

Mepolizumab MOA

A

anti-IL5

46
Q

Mepolizumab INdic

A

severe asthma in pts w eosinophils

47
Q

Mepolizumab AE

A

Injection site rxn

Hypersensitivity

48
Q

Chlorpheniramine, Fexofenadine MOA

A

anti H1R, 1st & second gen, respectively

49
Q

Chlorpheniramine, Fexofenadine INdic

A

allergic rhinitis

50
Q

Chlorpheniramine, Fexofenadine AE

A

sedation

mAchR AE in chlorpheniramine

51
Q

Montelukast MOA

A

LT-R antag

52
Q

Montelukast indic

A

asthma

allergic rhinitis

53
Q

Montelukast AE

A

Neuro crap

54
Q

Which drugs have a reversing response?

A

Albuterol

API

55
Q

Albuterol MOA

A

B2 ag

56
Q

Albuterol indic

A

asthma

57
Q

Albuterol AE

A 
tremor
CNS effects
Cardiac stim
-Inc HR
-palpitations
58
Q

EPI MOA

A

a1, B1, B2 ag

Immuno (4 decks)

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