DRUGS

Question 1

Give 2 examples of synergy

Answer 1

TMP + SMX (trimethoprim + sulfonamide)

AG’s + Pens (Gentamicin + ampicillin)

Question 2

Penicillins

Answer 2

Target late step in cell wall synthesis (transpeptidase)
Natural: Pen G (increase t1/2, treponema tx: syphillis)
Anti-staph: nafcillin (naf for staph, MSSA)
Amino: amoxixillin (broad spectrum, Gram + and some gram -)
Anti-pseudomonal: pipericillin (very broad, pseudomonas and many other Gram -)

Question 3

Cephalosporins

Answer 3

1st gen: Cephalexin (PHIRST) (mild rash)
2nd gen: Cefaclor (2 C’s) (good for anaerobes… bacteroides and clostridium)
3rd gen: Cefotaxime(meningitis), Ceftriaxone (don’t try axing neonates) (TRI-AX) (tx: gonorrhea)
4th gen: Cefepime (VERY broad) (hospital acquired infections) (resistant to B-lactamase)
5th gen: Ceftaroline (tx: MRSA) (resistant to B-lactamase)

Question 4

Carbapenems

Answer 4

Imipinem + Cilastatin= VERY BROAD
Cilastatin moa: dihydropeptidase inhibitor
SE: seizures if you dont adjust in kidney failure

Question 5

Monobactams

Answer 5

Aztreonam (diff structure)