drugs Flashcards
What is Rituximab?
Anti CD20 ab
- B cells malignancies and immune therapy
- induces ab dependent cellular toxicity ADCC
What re Ofatumumab and Obinutuzumab?
Next generation Anti- CD20
- outperform Rituximab with low grade lymphomas
What is a CTLA-4 blockage? and Name of drug?
Ipilimamab
- melanoma treats
- bindings of CTLA-4 to B7 (CD80/86) inhibits co-stimulation (CD28–> B7) which then T cell cannot be activated
What is Pd-1 blockage?
Pembrolizumab and Nivolumab
- PD-1 on T cell binds to PD-1L and inhibits T cell acitvation
What is so bad about APL?
emergency secondary to DIC
Faggot cells
What is the treatment for APL?
All trans retinoic acid
what are the pathways for Nausea and what substaces are used?
Central- Substance P- blocked by NK receptor antagonists
Peripheral- Serotonin
What is Zoledronic acid?
potent anti-resportive therapy
What is polyethylene glycol used for?
Constipation treatment
- for vicana, 5FU and irinotecan slow gut down
Wht is needed for EGFR abs to work?
wild type Ras and Raf downstream to EGFR
- they are usually always on in cancer
hat is Panitumumab?
EGFR ab with fewer infusion rxns and for HPV and colong cancer
What is Ibrutinib?
Bruton Kinase inhibitor for CLL treatment
- common resistance is C481S
What is sirolimus and its MOA?
Prevent clonal expansion of T and b cells
- Binds FKBP and inhibitor MTOR and cell progess ion
what is mycophenolate mefetil?
inhibits inosine monophosphate dehydrogenase which is needed for the making of T and b cells
What are the anti-IL-2 drugs?
Daclizumab and Basiliximab
