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IHO final > Diebel > Flashcards

Diebel Flashcards

1
Q

What is the receptor for Fc region of IgG?

A

CD32

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2
Q

What is IgG best at?

A

Neutralizing toxins

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3
Q

What is IgA best at?

A

Best at antiviral activity (only one)

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4
Q

What is IgM best at?

A

Complement fixation

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5
Q

What is the role of TDT?

A

adds random and a few non-templated nucleotides after exonucleases have chewed up nucleotides

  • adds a ton of diversity
  • Heavy chain only
  • only works 33% of the time
  • somatic mutation
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6
Q

What is the role of AID?

A

Adds even more mutation and diversity

  • only in the periphery
  • somatic hypermutation
  • Activation- induced cytidine deaminase
  • exchanges C’s for U’s then mismatched U:G appear
  • Uracil DNA glycosylase removes U and DNA polymerase fills gap with random
  • also helps in class switching
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7
Q

What activated TH1 and what does it produce?

A

IL-12, INFy and IL-18

INFy, TNF-B

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8
Q

what activated TH2 and what does it produce?

A

IL-4

IL4, IL-5, IL-13

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9
Q

what activated TH17 and what does it produce?

A

IL-6 and IL-23 and TGF-B

IL-17 , IL-22

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10
Q

what activated Tfh and what does it produce?

A

IL-6 and IL-21

IL-4, IL-21

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11
Q

what activated Treg and what does it produce?

A

IL-2 TGF-b

TGF-b, IL-10

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12
Q

What chain of the TCR is like heavy and what is like like chain?

A

Alpha is like light

Beta is like heavy

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13
Q

Do T cells have somatic hypermutation?

A

No but they do increase their diversity by alternative jointing of the D sequences like VJ or VDJ or VDDJ
- also has TDT for somatic mutation

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14
Q

What is unique to DC’s in terms of presenation?

A

Cross pressenation

- can present both ag on MHC 1 and 2 at the same time

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15
Q

What are the polymorphisms for MHC 1 and 2?

A

6 for 1 (only 3 alpha chains and a Beta-2 microglobulin)

12 for 2 (heterodimer with alpha and beta)

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16
Q

What are the combinations for MHC 1?

A

HLA a from mother or father
B and C
- codominance
- they are all expressed

17
Q

HLA-B27 ass?

A

90x akylosing spondylosis

18
Q

DR2?

A

130x for narcolepsy

- Ms hay fever and SLE

19
Q

A3/B14?

A

90x for hemochromatosis

20
Q

DQ2/GQ8?

A

Ciliac

21
Q

CR3?

A

DM type 1

Graves dz

22
Q

DR4?

A

RA and DM 1

23
Q

B53?

A

malaria in children

24
Q

Tap 1 and 2, Calnexin, ERAAP, Tapsin and Calreticulin are ass with what pathway ?

A

Cytosolic

25
Q

Invariant chain, clip protein and HLA-DM are ass with what pathway?

A

Endocytic

- DM moves the clip out of the binding site of MHC2 where HLA-DO blocks this process from happening

26
Q

What is the ration of CD4 to CD8 cells supposed to be?

A

about 2 to one about 65%-35% respectively

27
Q

What is the role of L-BCCF IL3 and IL4?

A

initiates the process in B cell diff

28
Q

what is the receptor needed for B cell development and final maturation?

A

CD79a/b

29
Q

What are B1 cells and how do they work?

A

T-independent B cells

  • high levels of IgM and very litter to nor memory
  • peritoneal and plural cavities
30
Q

What are the subdivision of B1 cells?

A

Type 1 and Type 2

31
Q

What does Type 1 recognize ag?

A

LPS thru 4/4 TLR

- stimulates both immature mature b ells

32
Q

What does type 2 recognize as ag?

A

Large polysaccharides with repeated antigenic determinants

- only stimulate mature b cells trough BCR

33
Q

what are B2 cells and how do they work?

A

They are T-DEPENDENT B cells

  • high levels of IgG with memory
  • classic B cell as we know it
34
Q

what is the progression of T cell dev?

A

SC-> lymphoid progen> DN1>2>3>4>DP> either CD4/8

35
Q

When is CD44 expressed and why? 25 and c-kit?

A

CD44- DN1 and 2 stage functions to relocated to Thymus
c-Kit- DN2 stage receptor for stem cell factor
CD25- DN2 and 3 this is an IL-2 receptor
CD3- DN3 and 4

36
Q

Does TCR express CD4/8 during recombination?

A

no

IHO final (7 decks)

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