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3rd Year General Revision > Drugs > Flashcards

Drugs Flashcards

1
Q

What class: phenelzine?

A

MAOI

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2
Q

What class: Isocarboxazid?

A

MAOI

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3
Q

What class: Tranylcypromine?

A

MAOI

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4
Q

What class: Moclobemide

A

RIMA

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5
Q

What class: Amitryptiline

A

TCA (non-selective)

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6
Q

What class: Clomipramine

A

TCA

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7
Q

What class: Imipramine

A

TCA (non-selective)

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8
Q

What class: Noritryptiline

A

TCA (NA selective)

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9
Q

What class: Dosulepin

A

TCA

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10
Q

What class: Fluoxetine

A

SSRI

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11
Q

What class: (Es)citalopram

A

SSRI

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12
Q

What class: Sertraline

A

SSRI

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13
Q

What class: Fluvoxamine

A

SSRI

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14
Q

What class: venlaxafine

A

SNRI

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15
Q

What class: duloxetine

A

SNRI

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16
Q

What class: Reboxetine

A

NARI

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17
Q

What class: Mirtazapine

A

NaSSA

18
Q

Anterior cingulate

A

Attention/conflict/response selection

19
Q

Orbitofrontal cortex

A

Relative reward preference/rule learning

20
Q

Class of drug which could be used to treat premature ejaculation

A

SSRI

21
Q

Which SSRI’s inhibit CYP450?

A

Fluoxetine, paroxetine

22
Q

Most common adverse effects of SSRIs

A
  • sexual dysfunction
  • GI (nausea, dyspepsia, constipation, diarrhoea)
  • short term anxiety is fairly common
  • in young people, there is probably an increased risk of self-harm (&suicide) in the first few weeks
23
Q

TCA adverse effects

A 
–  Constipation
– Dry mouth
– Blurred vision
– Effects on cardiac function
– Postural hypotension (cholinergic and adrenergic blockade causing failure of peripheral orthostatic reflexes)
24
Q

What does MAO A metabolise?

A

NA, 5-HT and tyramine

25
Q

What does MAO B metabolise?

A

DA, tryamine and phenylethylamine

26
Q

Name 3 irreversible MAOIs

A

Phenelzine
Isocarboxazid
Tranylcypromine

27
Q

This type of drug is really good for atypical depression

A

MAOI

28
Q

This type of drug results in increased NA and 5-HT storage and availability for release

A

MAOIS

29
Q

Which foods could cause a tyramine crisis if you are on MAOIs?

A

Cheese, yoghurt, yeast extracts, meat, alcohol, broad beans, pickled herring

30
Q

Symptoms of MAOI hypertensive crisis

A

Flushing headache, increased BP

-Rarely CVA

31
Q

Treatment for MAOI hypertensive crisie

A

Alpha blockade –> PHENTOLAMINE / CHLORPROMAZINE !!! Learn !!!

32
Q

Antipsychotic which may be antidepressant at low dose

A

Flupentixol

33
Q

Types of mood stabiliser

A

Anti-convulsant drugs
“Atypical” antipsychotics
Others (lithium carbonate, NIMODOPINE)

-most mood stabilisers are anti-epileptic drugs (anti-convulsants)

34
Q

How does lamotrigine work?

A

Blocks Na+ channels, although it doesn’t work directly via GABA, the overall effect is to reduce excitability and cell firing (potentially useful if you have over-excitable neurones)
-Lamotrigine may also inhibit 5-HT (plus NA and DA uptake as well)

35
Q

One of the oldest mood stabilisers

-method of action unkown

A

Lithium

  • method of action unknown
  • but probably to do with inhibition of glycogen synthase kinase 3 (GSK-3)
36
Q

True anti-psychotic activity is related to their affinity for which receptor?

A

The D2 receptor

-desired effect is DA blockade in the mesolimbic systems

37
Q

Why can you get adverse effects such as movement disorders and hyperprlactinaemia with anti-psychotics?

A

Due to the DA blockade in the nigrostriatal and tubero-infundibular pathways)

38
Q

If you block the nigrostriatal pathways what happens?

A

Movement disorders

39
Q

If you block the tubero-infundibular pathways, what happens?

A

Hyperprolactinemia

40
Q

Which 5-HT receptors increase anti-psychotic affinity

A

5-HT2c and 5-HT2a

41
Q

Which 5-HT receptors decrease anti-psychotic efficiency

A

5-HT1a

3rd Year General Revision (17 decks)

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