Drugs

Question 1

Macrolide SEs

Answer 1

GI
hearing loss
prolonged QT –> torsades
thrombophlebitis

Question 2

Ketolide SEs

Answer 2

hepatotoxicity
prolonged QT
myasthenia gravis exacerbation

Question 3

Tetracycline SEs

Answer 3

skin
bone/teeth
GI, liver, renal
Vertigo (esp Mino)

Question 4

Tigecycline SEs

Answer 4

N/V
inc mortality in HAP
eosinophilic pneumonia
same SEs as tetra

Question 5

Quinolone SEs

Answer 5

2nd gens have prolonged QT
cartilage damage
tendonitis
C dif selection
inc theophylline
Seizures

Question 6

Linezolid SEs

Answer 6

thrombocytopenia
neutropenia
abnormal LFTs
serotonin syndrome with hyperpyrexia

Question 7

Daptomycin SE

Answer 7

myositis

Question 8

Chloramphenicol SE

Answer 8

aplastic anemia

Question 9

Cefuroxim SE

Answer 9

serum sickness

Question 10

Ceftoraline mechanism

Answer 10

PBP2a

Question 11

Carbepenems mechanism

Answer 11

PBP2

Question 12

Aminoglycoside SE

Answer 12

major nephrotoxicity

ototoxicity & vestibular toxicity

Question 13

Pulmonary htn drug categories

Answer 13

prostanoids
endothelin receptor antagonists ("tan")
phosphodiesterase inhibitors ("fil")

Question 14

Amphotericin B SEs

Answer 14

renal toxicity & infusional toxicity

Question 15

Seen in all azoles

Answer 15

cholestasis

Question 16

ketoconazole SEs

Answer 16

liver enzyme abnormalities
anti-thyroid function (impairs thyroglobulin iodination)
decreased testosterone & cortisol levels

Question 17

Azoles active against molds

Answer 17

itraconazole
vorconazole
posaconazole

Question 18

Itraconazole SEs

Answer 18

dec cardiac systolic function
edema
hypokalemia

Question 19

voriconazole SEs

Answer 19

visual toxicity
liver enzyme abnormalities
nephrotoxicity
skin changes

Question 20

Echinocandins toxicity profile

Answer 20

excellent

Question 21

Adamantanes SEs

Answer 21

anticholinergic

CNS toxicity

Question 22

Ribavirin SEs

Answer 22

aerosolized: bronchospasm, reversible pulmonary deterioration
systemic: bone marrow tox, hemolysis, anemia

Question 23

acyclovir mechanism

Answer 23

via thymidine kinase

chain terminator

Question 24

acyclovir SEs

Answer 24

renal dysfunction secondary to tubular precipitation

Question 25

Ganciclovir SEs

Answer 25

leukopenia

Question 26

Cidofovir half life

Answer 26

33hrs

Question 27

cidofovir SEs

Answer 27

nephrotoxicity

Question 28

foscarnet SEs

Answer 28

renal function impaired

anemia