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Pulmonary > Drugs > Flashcards

Drugs Flashcards

1
Q

Macrolide SEs

A

GI
hearing loss
prolonged QT –> torsades
thrombophlebitis

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2
Q

Ketolide SEs

A

hepatotoxicity
prolonged QT
myasthenia gravis exacerbation

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3
Q

Tetracycline SEs

A

skin
bone/teeth
GI, liver, renal
Vertigo (esp Mino)

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4
Q

Tigecycline SEs

A

N/V
inc mortality in HAP
eosinophilic pneumonia
same SEs as tetra

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5
Q

Quinolone SEs

A 
2nd gens have prolonged QT
cartilage damage
tendonitis
C dif selection
inc theophylline
Seizures
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6
Q

Linezolid SEs

A

thrombocytopenia
neutropenia
abnormal LFTs
serotonin syndrome with hyperpyrexia

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7
Q

Daptomycin SE

A

myositis

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8
Q

Chloramphenicol SE

A

aplastic anemia

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9
Q

Cefuroxim SE

A

serum sickness

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10
Q

Ceftoraline mechanism

A

PBP2a

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11
Q

Carbepenems mechanism

A

PBP2

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12
Q

Aminoglycoside SE

A

major nephrotoxicity

ototoxicity & vestibular toxicity

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13
Q

Pulmonary htn drug categories

A 
prostanoids
endothelin receptor antagonists ("tan")
phosphodiesterase inhibitors ("fil")
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14
Q

Amphotericin B SEs

A

renal toxicity & infusional toxicity

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15
Q

Seen in all azoles

A

cholestasis

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16
Q

ketoconazole SEs

A

liver enzyme abnormalities
anti-thyroid function (impairs thyroglobulin iodination)
decreased testosterone & cortisol levels

17
Q

Azoles active against molds

A

itraconazole
vorconazole
posaconazole

18
Q

Itraconazole SEs

A

dec cardiac systolic function
edema
hypokalemia

19
Q

voriconazole SEs

A

visual toxicity
liver enzyme abnormalities
nephrotoxicity
skin changes

20
Q

Echinocandins toxicity profile

A

excellent

21
Q

Adamantanes SEs

A

anticholinergic

CNS toxicity

22
Q

Ribavirin SEs

A

aerosolized: bronchospasm, reversible pulmonary deterioration
systemic: bone marrow tox, hemolysis, anemia

23
Q

acyclovir mechanism

A

via thymidine kinase

chain terminator

24
Q

acyclovir SEs

A

renal dysfunction secondary to tubular precipitation

25
Q

Ganciclovir SEs

A

leukopenia

26
Q

Cidofovir half life

A

33hrs

27
Q

cidofovir SEs

A

nephrotoxicity

28
Q

foscarnet SEs

A

renal function impaired

anemia

Pulmonary (6 decks)

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