Drugs Flashcards
what is pain
physical/electrical input coming from the body and is combined with historical and contextual factors in the brain
can be from actual tissue damage or perceived tissue damage
personal experience of pain influenced by
biological psych and social factors
central sensitization
NS changes in ways that makes it more responsive to input that would not be painful normally
nerves adapt by increasing resting levels of excitement
pain persists for longer than 3 months
how do NSAIDs work
suppress inflammation by inhibiting the COX enzyme
why use NSAIDs
good at treating pain caused by slow tissue damage such as arthritis
works well to fight pain, menstrual cramps, headaches
reduce clotting action
NSAIDS are typically not used for more than
10 days unless doc says otherwise
how does acetaminophen work
blocks pain by inhibiting the synthesis of prostaglandin in the CNS but not in peripheral system
reduces pain signals
T/F: tylenol acts as an analgesic and reduces fever because of anti-inflammatory or antiplatelet properties
false, no anti-inflammatory of antiplatelet properties
does acetaminophen cause GI irritations
not so often
processed through liver
using tylenol and advil together
safe
common
do not exceed prescribed dose
best to take 2-4h alternated
work differently to help with pain
topical NSAIDs
direct application to painful site to produce local-pain relieving effect which avoids whole body distribution of the drug at physiological levels
more superficial pain conditioning
ethical considerations for NSAIDs
mediate pressure from players, coach, etc.
masking the pain?
benefits of corticosteroid injections
steroid hormone
widely used to help decrease inflammation and pain by delivery of potent anti-inflammatories
concerns of corticosteroids injections
length of benefits and safety concerns that limit the frequency of use
effectiveness of intra articular therapies in OA
more effective than placebo 1-2 post injc.
4-24 little evidence
prolonged use no good
higher doses for longer treatment associated with chondrotoxicity
recommended for short term use