Drugs Flashcards

1
Q

act mainly on the distal convoluted tubule?

A

bendroflumthiazie- thiazide diuretic

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2
Q

cardio selective bbs

A

metoprolol, bisoprolol,atenolol

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3
Q

non selective

A

propanolol

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4
Q

clopidogrel

A

inhibits adp from binding to platelt receptors

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5
Q

rivaroxaban

A

direct inhibtion of factor xa

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6
Q

dabigatran

A

direct thrombin inhibitor

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7
Q

increased effect of anti thrombin

A

heparin/lmwh

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8
Q

inhibits vitamin k

A

warfarin

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9
Q

action of calcium channel blockers

A

vasodilators

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10
Q

dihydropyridines examples

A

amlodipine
nifedipine etc

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11
Q

what do dihyss mainly act on

A

smooth muscle of blood vessels

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12
Q

side effect of dihys

A

reflex tachy as detected by sympathetic nervous system so increases heart rate in order to maintain perfusion

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13
Q

side effects of dihys

A

flushing
dizzy
peripheral oedem a
gingival hyperplasia

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14
Q

nondihys examples

A

verapamil
diltiazem

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15
Q

where does non dihs mainly act

A

on the heart itself

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16
Q

what class are ccbs

A

class IV

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17
Q

what do non dihys treat

A

tachyarrhytmias which cause increased HR

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18
Q

which non dishy is more sleective

A

verapamil

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19
Q

what is non dihy contraindicated in

A

bradycardia and heart failure

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20
Q

what might ccbs cayse

A

brady and constipation

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21
Q

can diltiazem act as a vasodilator too

A

yes

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22
Q

what are non dihys mainly used for

A

chronic stable angina, hypertesion

23
Q

what are dihys mainly used for

A

hypertension as they act on the vessels

24
Q

non selective beta blockers examples

A
  • Propranolol
  • Timolol
  • Nadolol
  • Sotalol
25
Q

selective bb examples

A

Atenolol
Metoprolol
Bisoprolol

26
Q

where do selective bb act

A

b1

27
Q

where do non selectives act

A

b1 and 2

28
Q

whcih bb can be usedin asthma

A

selective as they dont act on b2 to bronchoconstrict

29
Q

action of locking b1

A

decreased hr and contractility

30
Q

hypertensive emergency drug

A

labetalol- non selecetive

31
Q

class I anti arrhythmic

A

sodium channel blockerscl

32
Q

class 2 anti arrhytmics

A

beta blockers

33
Q

class 3 anti arrhytmics

A

potassium channel blockers

34
Q

class iv anti arrhythmics

A

calcium channel blockers

35
Q

where do diuretics act

A

kidneys to increase production of urine to eliminate water from body

36
Q

what are thiazides secreted by

A

proximal convulated tubule

37
Q

thiazide like diiuretic example

A

indapamide

38
Q

what are longer lasting- loops or thiazides

A

thiazides

39
Q

what are most potent thiazides

A

loops

40
Q

where do loop diuretics act

A

on thick ascending loop, na,k,cl co transporter

41
Q

what are loops indictaed for

A

hyperkalaemia and hypercalcaemia

42
Q

what might short term thiazides cause

A

hyponaetraemia

43
Q

what might thiazides cause

A

hypercalcaemia and hyperglycameia

44
Q

phase 0

A

depolarisation and sodium into cell rapdily

45
Q

phase 1

A

initial repolarisation , potassium outward current

46
Q

phase 2

A

plateau phase
calcium into cell

47
Q

phase 3

A

calcium channel closes, potassium still open

48
Q

phase 4

A

resting mmebrnane

49
Q

sodium channel blockers

A

slows depolarisation phase

50
Q

potassium blockers

A

slows all phases post 2
less potassium leaving cell so loger rate of repolaristion

51
Q

effects of potassium blockers

A

prolongs qt interval so may cause torsades de pointes

52
Q

example of potassium blocker

A

amiodarone

53
Q
A