Drugs

Question 1

Diphenhydramine:
Brand Name
Drug Class
Indication
Mechanism of Action
Dosing range

Answer 1

-Benadryl
-Antihistamine (first generation)
- Seasonal allergies, allergic skin reactions, insomnia, motion sickness
-Competes w/ Histamine for H1-receptor sites in the respiratory tract and vasculature
-25-50mg q4-6h (adult)

Question 2

Cetirizine:
Brand Name
Drug Class
Indication
Mechanism of Action

Answer 2

-Reactine
-Antihistamine
-seasonal allergies, urticaria/dermatolgical conditions
-an active human metabolite of hydroxyzine, is a histamine H1 receptor antagonist anti-allergic compound. Competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract.

Question 3

Loratadine:
Brand Name
Drug Class
Indication
Mechanism of Action
Dosing Range

Answer 3

-Claritin
-Antihistamine (second generation)
-Seasonal allergies, urticaria/dermatological conditions
-Selective blocking of histamine at H1-receptor sites
-10mg daily

Question 4

Naproxen
Brand Name
Drug Class
Indication
Mechanism of Action
Dosing Range

Answer 4

-Aleve, Naprosyn, Anaprox
-NSAID
-Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, dysmenorrhea, mild/moderate pain and inflammation, fever
-Non-selective inhibition of COX-1 and COX-2. Inhibition leads to decreases in prostaglandin production.
-250mg - 500mg BID (variations depending on dosage form used)

Question 5

Diclofenac (Salts)
Brand Name
Drug Class
Indication
Mechanism of Action
Dosing Range

Answer 5

-Voltaren (PO, PR, gel), Cambia, Pennsaid
-NSAID
-Fever, pain (mild to moderate), inflammation (each salt has diff approved indications)
-Inhibits COX-1 and COX-2. Inhibition leads to decreases in prostaglandin production. Evidence suggests some preferential COX-2 inhibition.
-PO - 25-100mg daily-tid (max 100mg daily)

Question 6

Ibuprofen
Brand Name
Drug Class
Indication
Mechanism of Action
Dosing Range
Maximum Daily Dosage

Answer 6

-Advil, Motrin
-NSAID
-Fever, pain, inflammation
-Non-selective inhibition of COX-1 and COX-2. Inhibition leads to decreases in prostaglandin production.
- 200-600mg tid-qid
-maximum daily dosage ranges from 1200 mg/day OTC use or 2400mg/day Rx depending on indication