Drugs

Question 1

Prednisone

Answer 1

Activation of glucocorticoid receptor, altering

gene transcription; inhibit phospholipase A2

Question 2

Cyclosporine

Answer 2

Cyclosporine-cyclophilin complex inhibits

calcineurin

Question 3

Tacrolimus

Answer 3

Inhibit calcineurin by binding to FK506

immunophilin

Question 4

Sirolimus (rapamycin)

Answer 4

Inhibit IL-2 signaling pathway by binding to

cyclophilin; inhibit mTOR

Question 5

Tofactinib

Answer 5

Inhibit JAK family (JAK3 and some JAK1)

Question 6

Mycophenolate mofetil

Answer 6

Blocks de novo GTP synthesis by inhibiting

IMP dehydrogenase

Question 7

Lenalidomide

Answer 7

Potent inhibitor of TNF-α

Pregnancy is contraindicated

Question 8

Aldesleukin

Answer 8

Activates IL-2 receptors on T, B, and NK cells

Question 9

Anakinra

Answer 9

IL-1 antagonist; prevent IL-1 from binging to

its receptor

Question 10

Mepolizumab

Answer 10

Binds IL-5 and selectively inhibits eosinophilic

inflammation

Question 11

Tocilizumab

Answer 11

Recombinant IgG; inhibits IL-6 signaling by

binding to its receptor

Question 12

Ustekinumab

Answer 12

Bind to p40 subunit of IL-12 and IL-23
cytokines and prevents interaction with
receptor

Question 13

Omalizumab

Answer 13

Anti IgE MAb; prevent IgE binding to mast

cells and basophils

Question 14

Basiliximab

Answer 14

Mouse-human IgG, binds to CD25 (IL-2

receptor on activated lymphocytes)

Question 15

Vedolizumab

Answer 15

Targets α-4-beta-7 integrin in GI tract (which

is a mediator of GI inflammation)

Question 16

Abatacept

Answer 16

Blocks T-cell activation by interfering with

CD28-APC rxn

Question 17

Infliximab

Answer 17

Binds to TNF-α and prevents it from

activating its receptor

Question 18

Etanercept

Answer 18

Binds to TNF-α and inhibits lymphotoxin-α

Question 19

Rituximab

Answer 19

Binds to CD20 antigen on B lymphocytes and
recurits immune effector functions to
mediate cell lysis

Question 20

Nivolumab

Answer 20

Block PD ligand-1 on tumor cells, supressing T

cell activity

Question 21

Leflunomide

Answer 21

Prodrug of pyrimidine synthesis inhibitor

inhibit dihydroorotate dehydrogenase

Question 22

Azathioprine

Answer 22

Prodrug of 6-mercaptopurine; inhibit de novo
purine synthesis, inhibiting lymphocyte
production

Question 23

Methotrexate

Answer 23

Inhibit DHFR (dihydrofolate reductase),
inhibiting synthesis of thymidylate, purine
nucleotides, serine and methionine

Question 24

IVIG

Answer 24

IV polyclonal human IgG (usually), prepared
from thousands of healthy donors, no single
specific antigen is the target