Drugs Flashcards
What is Serotonin Syndrome?
A vague presentation due to the sudden increase in serotonin levels within the brain
What are some cognitive symptoms of serotonin syndrome?
Headaches Agitation Hypomania Confusions Coma
What are some autonomic symptoms of serotonin syndrome?
Shivering Sweating Hyperthermia Tachycardia Nausea Diarrhoea
What are some somatic symptoms of serotonin syndrome?
Myoclonus
Hyperreflexia
Tremor
How is serotonin syndrome managed?
Supportive management
What are some symptoms of discontinuation syndrome?
Sweating Shakes Agitation Insomnia Headaches Irritability Nausea Vomiting Paraesthesia Clonus
Which SSRIs commonly give discontinuation syndrome?
Paroxetine
Venlafaxine
How do SSRIs work?
Increase serotonin levels by reducing serotonin uptake
What are some example SSRIs?
Sertraline
Citalopram - Caution RE QTc prolongation
Fluoxetine
Paroxetine
What are some side-effects of SSRIs?
Restlessness Agitation on initiation Nausea GI Disturbance Headache Weight changes Sexual dysfunction GI Bleeding Suicidal ideation
How do SNRIs work?
Increase Serotonin and Noradrenaline levels by reducing uptake
What are some example SNRIs?
Duloxetine
Venlafaxine
What are some example Tricyclic Antidepressants?
Nortriptylline
Amitryptylline
How do Monoamine Oxidase Inhibitors work?
Work on serotonin and dopamine
What are some example MAOIs?
Phenelzine
Isocarboxazid
Moclobamide
Tranylcypromine
