Drug Therapy In Older Clients Flashcards
Administration of many drugs together. This increases chances of toxicity and interactions =
Polypharmacy
Are herbal remedies considered drugs?
Yes
May cause confusion, falls, malnutrition, renal/ liver dysfunction, non-adherence =
Polypharmacy
People over the age of 65 buy what percentage of all prescriptions?
35%
People over the age of 65 buy what percentage of all OTC meds sold in America?
Over 40%
The average older adult living at home uses how many prescription + OTC drugs?
4-5 Prescription
2 OTC
Most commonly used OTC’s =
Analgesics, anti-inflammatory drugs, laxatives, and antacids
Diuretics, Potassium Salts, Histamine2-antagonists, Nitroglycerin, Insulins, Cardiac Glycosides, Beta-blockers, Anti-anxiety drugs, and Hypertensives =
Most commonly used prescribed meds
Should you encourage the use of the SAME pharmacy for all prescription needs?
Yeah
Do many people know what pills that they are taking are?
No
There’s a 100% chance of drug interaction when taking how many drugs?
8 or more
The more drug taken, the more-
The chance for side effects
The goal of drug therapy is to-
Maintain health with the fewest drugs possible
What is the purpose of Brown Bag Sessions?
To check appropriateness of meds for a patient
What may you discover during a brown bag session?
Inappropriate drugs, duplicated drugs, expired drugs, supplements or OTC’s not listed elsewhere
What’s a brown bag session?
When all meds are brought into doctor’s office during visits
What kinds of GI changes can affect drug therapy?
Increased pH, decreased peristalsis, motility, and first pass effect
What kinds of cardiac changes can affect drug therapy?
Decreased cardiac output leads to decreased circulation
What kinds of hepatic changes can affect drug therapy?
Decreased enzyme function and blood flow
What kinds of renal changes can affect drug therapy?
Decreased blood flow, decreased nephrons, decreased GFR
Absorption, distribution, metabolism, and excretion can all be slowed by-
The physiologic changes in an older adult
Oral meds may not respond as quickly in older adults due to-
GI changes
Decreased cardiac output leads to-
Reduced perfusion in the GI tract
Reduced perfusion in the GI tract leads to-
Delayed, less thorough, and less reliable removal of drugs from intestinal lumen.
Can reduced perfusion in the GI tract cause a reduced absorption of substances?
Yes
As you get older, your liver should remain functional, but your ability to metabolize a drug may decline. Does this make drug accumulation an important issue?
Yes
Does extended half-lives warrant close monitoring in older adults?
Yup
Renal changes, CV disease, dehydration, and kidney disease may increase a drug’s half-life by up to-
40%
Due to a drug remaining in the body longer, the risk of what increases?
Adverse Effects
As you get older, what changes in body composition occur?
Weight decreases, fat % increases
Do older people experience a decline in total body water?
Yes
Hepatic =
The liver
Absorption, distribution, metabolism, and excretion are all apart of-
Pharmacokinetics