drug therapy for the treatment of infection - part 3 Flashcards
herpres drugs
famciclovir
acyclovir
valacyclovir
FAVs
can cause thrombocytopenic purpura (rash)
cytomegalovirus drugs
ganciclovir
pregnancy test before and after
bone marrow supression
birth defects
flu drugs
oseltamivir (tamiflu)
ribavirin
oseltamivir (tamiflu) - given within 48 hours
ribavirin - inhaled
ribavirin
black box warning: significant teratogenic
hep b and c drugs
nucleotide analogs
pancreatitis
middle back pain, fever, vomiting, tachycardia
viral hep and HIV drugs
what is important for pt teaching for these drugs
- Closely Adhere to Treatment Regimen
- Missing doses can cause replication of HIV and cause resistant viral strains
fungal drugs - polyeye
amphotericin B
Highly toxic – for serious fungal infections only
Black Box Warning!
Multiple organ failure
Respiratory arrest
Cardiac arrest
lipid form with renal patients
amphotericin B
o Prevent interactions – **aminoglycosides - increases risk of nephrotoxicity
o **Must infuse with Dextrose and flush before and after with Dextrose!
o Assess for phlebitis
fungal drugs
azoles
liver toxicity due to hepatic necrosis
echinocandins
caspofungin
micafungin
Highly bound to plasma albumin
Assess during administration because drug binds to albumin
assessment during admin for first 15 mins for hypersensitity reactions
terbinafine
black box warning: hepatotoxicity
what is important for parasitic infections
no vax - prevention is key !
antimalarials
Chloroquine phosphate
Hydroxychloroquine
Mefloquine
must be given before and after travel
retinal toxicity and EKG changes
inhibits prostagladin effects
amebicides
metronidazole
treats amebiasis
watch liver function
avoid alcohol
sacbicides/pediculicides
lindane
black box warning:
CNS toxicity > seizures > death
