drug therapy for the treatment of cancer Flashcards
alkalating agents
describe cyclophosphamide
- bladder toxicity
- drink 2 L of fluid
alkalating agents
describe cisplatin
- must verify pt line prior to admin
- watch for extravasation
what do we do for cisplatin extravasation
- Stop the infusion
- Disconnect tubing (leave cannula/needle in place)
- Gently aspirate extravasated solution (do NOT flush the line)
- Initiate sodium thiosulfate antidote
Elevate extremity.
antineoplastic hormone inhibitors
describe tamoxifen
- breast cancer tx
- decreases estrogen
- double glove!
- need baseline bone mineral density testing > can develop osteoporosis due to low estrogen
cytoprotectants
what do cytoprotectants do
Reverse adverse effects of cancer drugs
protectors
reduce side effects of chemo
cause bone marrow suppression
cytoprotectants
describe epotein alfa
- used for anemia
- increases RBC
cytoprotectants
describe filgastim
helps with WBC production
cytoprotectants
describe leucovorin
works with folic acid
luke is frolicking
cytoprotectants
describe human interleukin 11
helps with thrombocytopenia
thrombopoietin - PLTs increase to prevent bleeding
what is tumor lysis syndrome
killing a bunch of cells all at once
shit is dumped into bloodstream
signs of tumor lysis syndrome
- hyperkalemia
- hyperphosphatemia
- hyperuricemia
- hypomagnesemia
- hypocalcemia
- acidosis
hyper KPU
hypo MC
what is the tx for tumor lysis syndrome
- aggresive hydration
- sodium bicarb (tx for acidosis)
- allpurinol (tx for hyperuricemia)
