Drug Targets: Ion Channels

Question 1

Voltage gated sodium channels comprised of?

Answer 1

I protein
4 domains
6 transmembrane regions

Question 2

Voltage gated sodium channels are family of now many genes?

Answer 2

9 genes (SCNA1-9 = NaV1.1-1.9)

Question 3

NaV 1.5 associated with what disorders?

Answer 3

Arrhythmic

Question 4

NaV 1.4 associated with what disorders?

Answer 4

Mytonic and paralytic

Question 5

NaV 1.1-3 and 1.6 associated with what disorders?

Answer 5

Epileptic

Question 6

NaV 1.6-9 associated with what disorders?

Answer 6

Pain-related disorders

Question 7

Overactivity of voltage gated Na channels result in?

Answer 7

Disorders

Question 8

K+ channels allow efflux of?

Answer 8

Positive ions, keeps membrane potential of cells relatively negative

Question 9

Paroxysms

Answer 9

Brief, stereotyped attacks of motor or sensory phenomena that mimic epilepsy

Question 10

What do conventional anticonvulsants do?

Answer 10

Decrease excitation by blocking na/ca channels or altering glutamate

Question 11

What is retigabine?

Answer 11

Boosted voltage gated k channel that was encoded by the KCNQ gene = increase inhibition of nerve