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Pharmacodynamics > Autonomic Nervous System > Flashcards

Autonomic Nervous System Flashcards

1
Q

Two systems of neurone

A

Sympathetic and parasympathetic

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2
Q

Origin of parasympathetic

A

Cranial sacral

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3
Q

Origin of sympathetic

A

Thoracic lumbar

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4
Q

Location of ganglia for ps and s system

A

Parasympathetic - ganglia in target organ
Sympathetic- ganglia next to spinal cord

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5
Q

All preganglionic are lightly myelinated - true or false

A

True

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6
Q

Parasympathetic has long or short first nerve?

A

Long

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7
Q

Cranial nerve x known as?

A

Vagus nerve

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8
Q

Receptor at ganglia is called?

A

Nicotinic

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9
Q

At preganglia this neurotransmitter is released

A

Acetylcholine

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10
Q

Final chemical produced by sympathetic

A

Noradrenaline

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11
Q

Final chemical of parasympathetic

A

Acetylcholine

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12
Q

Increase cardiac rate and force is what effect?

A

Sympathetic

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13
Q

What type of effect is sweat?

A

Sympathetic effect

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14
Q

Sympathetic target what receptors?

A

Adrenoreceptors

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15
Q

Example of 5 adrenoceptors

A

a1, a2, B1, B2,B3

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16
Q

Parasympathetic target what receptors?

A

Muscarinic

17
Q

Types of muscarinic receptors (5)

A

M1, M2, M3, M4,M5

18
Q

What adrenoreceptors are galphas linked?

A

B1, B2, B3

19
Q

Increased PLC targets what adrenoreceptor?

A

a1

20
Q

What adrenoreceptor is galphai linked?

A

a2

21
Q

When activated protein kinase A do what?

A

Increase calcium release, activate potassium channels, increase calcium influx

22
Q

Faster heart rate and more forceful contraction caused by what adrenoceptor?

A

B1

23
Q

What does increased cAMP do (linked to heart)?

A

Activate protein kinase A, direct stimulation of ‘pacemaker’ ion channels

24
Q

What effect does a1 adrenoreceptor have?

A

Smooth muscle contraction, artery narrowing, radial smooth muscle contraction , widening of pupils

25
Q

PIP2 hydrolysis does what? , same for arteries and pupil

A

Broken down into IP3 (increases calcium release) and DAG (increase calcium influx) = smooth muscle contraction

26
Q

What effect does b2 adrenoreceptor have?

A

Smoothmuscle relaxation, airway and artery widening, bladder filling

27
Q

Effect of activated protein kinase A by b2 adrenoreceptors

A

Potassium channel activated, imnibition of GO mechanism in sm contraction

28
Q

What receptor involved in breakdown of glycogen, inhibition of glycogen formation and breakdown of lipids?

A

B2/ b3 adrenoreceptor

29
Q

Activated protein kinase A by b1/b2 does what?

A

Modulate various enzymes

Pharmacodynamics (17 decks)

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