Clinical Uses Of Agents That Modify Adrenoceptors And Cholinoceptors

Question 1

Cholinesterase breaks down?

Answer 1

Acetylcholine

Question 2

Adrenergic receptor vs cholinergic receptor

Answer 2

Adrenergic receptors are g-protein coupled receptors work for sympathetic nervous system
Cholinergic receptors are ligand gated/metabotropic /GPCRS receptors that bind to ACh neurotransmitters

Question 3

Two types of cholinergic receptors

Answer 3

Muscarinic and nicotinic receptors

Question 4

Cholinoceptorsinclude what type of receptors?

Answer 4

Muscarinic and nicotinic

Question 5

Muscarinic receptors vs nicotinic cholinergic receptors: uses what receptor activation?

Answer 5

Muscarinic = GPCRs
Nicotinic= ligand gated ion channel receptors

Question 6

Example of muscarinic receptor agonists

Answer 6

muscarine, bethanecol, pilocarpine

Question 7

Example of muscarinic receptor antagonists

Answer 7

Atropine, hyoscine(scopolamine) , pirenzepine (M1), ipratropium (poor solubility)

Question 8

Classic receptor antagonist for nicotinic cholinergic receptors

Answer 8

Tubocurarine, pancuronium,hexamethonium

Question 9

Classic receptor agonist for nicotinic cholinergic receptors

Answer 9

Nicotine, lobeline

Question 10

Pilocarpine works on what receptor?

Answer 10

A muscarinic receptor agonist

Question 11

Bethanecol works of what cholinoceptor?

Answer 11

A muscarinic receptor agonist

Question 12

Pilocarpine used to?

Answer 12

Treat glaucoma and dry mouth
- used in sweat tests

Question 13

Bethanecol used for?

Answer 13

Aid bladder/gastric emptying occasionally

Question 14

Succinylcholine works on what cholinoceptor?

Answer 14

Nicotinic agonist receptor

Question 15

What is succinylcholine used for?

Answer 15

In surgery-depolarising paralysis

Question 16

Example of clinical uses of cholinesterase blockers

Answer 16

• tacrine, donepezil or rivastigmine used in dementia
  -Neuromuscular disease such as myasthenia gravis or Eaton -lambert syndrome

Question 17

Example of beta 2 agonist and antagonist

Answer 17

Salbutamol=agonist
Timolol=antagonist

Question 18

Example of beta 1 agonist and antagonist?

Answer 18

Dobutamine=agonist
Atenolol-antagonist

Question 19

Example of beta 3 agonist

Answer 19

Mirabegron

Question 20

Ventolin also referred to as?

Answer 20

Salbutamol

Question 21

Use of adrenoceptor agonists(examples)

Answer 21

Asthma inhalers (salbutamol)
Cardiac stimulant (dobutamine/adrenaline)

Question 22

Prazosin

Answer 22

Alpha adrenoceptor blocker

Question 23

Blocking alpha 1 adrenergic receptors cause?

Answer 23

Relaxation of smooth muscle in the bladder neck, urethra and prostrate gland

Question 24

A pharmaceutical company creates a new beta 2 adrenoceptor agonist. What physiological response will this drug produce?

Answer 24

Relaxation of bronchial smooth muscle and arterial smooth muscle