Drug Targets in GIT

Question 1

Give the general layers of the cells in the GIT

Answer 1

Mucosa - Submucosa - circular muscle - longitudinal muscle - serosa

Question 2

Give the four principle functions of GIT

Answer 2

Secretion - Motility - Blood flow - Growth and repair

Question 3

What are the 3 principle mechanisms that control the GIT?

Answer 3

Endocrine hormones - Paracrine mediators - Neural transmisssion

Question 4

Give an example of an endocrine pathway in the stomach

Answer 4

Chemical stimulation of G-cell - Gastrin released into bloodstream - Interacts with CCK8 receptor on parietal cell - H+ released

Question 5

What are the 3 receptors on parietal cells that regulate K+-H+-ATPase pump activity?

Answer 5

M1 receptor - Histamine 2 receptor - CCK8 receptor

Question 6

What are the effects of a) adrenaline and b) acetylcholine on small intestine smooth muscle contractions?

Answer 6

a) stops contraction

b) increases contraction

Question 7

What are the receptors for the sympathetic system? Parasympathetic system?

Answer 7

alpha 1 and beta 2 - M1 and M2 receptors