Drug targets Flashcards
1
Q
occupation
A
is governed by affinity
2
Q
activation
A
is governed efficacy
3
Q
Drug a (agonist) >
A
Response
4
Q
drug b ( antagonist)
A
no response
5
Q
at equilibrium
A
the ratio is constant and KD is constant
6
Q
potency
A
indicates the dilution at which the drug will cause an effect
7
Q
how to calculate potency
A
1/EC50
8
Q
specificity/selectivity
A
action at the desired site vs action at an off-target site (propranolol vs atenolol)
9
Q
how to calculate selectivity
A
potency @ site a (desired) / potency @ site b (undesired)
10
Q
Drug targets ( mediators of normal functions)
A
receptors
ion channels
enzymes
carrier molecules
11
Q
re-uptake inhibitors
A
inhibit uptake of neurotransmitters from the synaptic cleft- build up of monoamines- dopamine/serotonin/noradrenalin
