Drug Stuff

Question 1

• Lipid modifying drugs?
• Anti plt?
• Anti anginal?
• LV dysfunction?
• Venous thrombosis composition?
• Arterial thrombosis composition?
• Intrinsic pathway? Test? Extrinsic? Test?
• CCB with reflex tachy? Used with what?
• BB contraindications?

Answer 1

• Statins
• Aspirin, clopidigrel
• Nitrates, BB, CCB’s
• ACE/ ARBs
• Fibrin rich; use anti coag
• Plt rich; use anti plt
• Long, PTT; Short, INR
• Nifedipine; BB
• Asthma, PVD, quick withdrawal

Question 2

• 4 muscular smooth muscles pathways?
• O2 supply: Drugs that effect regional flow? Coronary blood flow?
• O2 demand: Drugs that effect HR? Inotropy? Wall Tension: venous preload? Systolic afterload?

Answer 2

1. ) NO –> Inc. GTP –> Increase Phosphotase –> VD
2. ) Ca receptor –> Inc. Ca –> Inc. MLCK –> VC
3. ) a1 –> Inc. IP3 –> Inc. Ca –> Inc. MLCK –> VC
4. ) B2 –> Inc. ATP –> Inc. cAMP –> Inc. Phosphotase –> VD
   - Nitrates, CCB, BB; CCB’s, Nitrates
   - BB, CCB’s; BB, CCB’s; Nitrates; CCB’s