Drug Reactions Flashcards
immediate reactions occur ____ of the dose
in less than 1 hour
urticaria, angioedema, and anaphylaxis are ___ reactions
immediate
delayed reactions occur ___ of the dose
after one hour but usually 6 hours, sometimes months
exanthematous eruptions, fixed drug eruptions, systemic reactions (DIHS, SJS, TEN), vasculitis are examples of ___ reactions
delayed
w/ the exception of ___ allergy testing for skin reactions is useless
PCN
what is the most important info in determining if a rash is med related
timing
how soon after a med does an exanthematous eruption occur
7-10 days
risk factors for drug reactions
female, hx of drug rxn, HLA, EBV, HIV
widespread, symmetric erythematous macules and papules on the trunk and extremities
morbilliform (measles like)
exanthematous drug eruptions begin___ and spread to ___
begin on trunk and symmetrically spread to extremities
assoc sxs w/ exanthematous drug eruptions
pruritis, mild fever
exanthematous drug eruption tx
topical steroids, oral antihistamines
formation of a solitary erythematous patch or plaque that occurs at the site of exposure to the drug and can evolve to become a bulla and then an erosion
fixed drug eruption
laxatives, tetracyclines, metronidazole, sulfas, barbs, NSAIDs, salicylates, yellow food coloring involved in
fixed drug eruption
what areas do fixed drug eruptions affect
mouth, genitalia, face, sacral
