Drug Reactions Flashcards
Cardiovascular
Coronary vasospasm
Cutaneous flushing
Dilated cardiomyopathy
Torsades de pointes
Endocrine/Reproductive
Adrenocortical insufficiency
Hot flashes
Hyperglycemia
Hypothyroidism
GI
Acute cholestatic hepatitis, jaundice Diarrhea Focal to massive hepatic necrosis Hepatitis Pancreatitis Pseudomembranous colitis
Hematologic
Agranulocytosis Aplastic anemia Direct Coombs-positive hemolytic anemia Gray baby syndrome Hemolysis in G6PD deficiency Megaloblastic anemia Thrombocytopenia Thrombotic complications
Musculoskeletal/Skin/CT
Fat redistribution Gingival hyperplasia Hyperuricemia (gout) Myopathy Osteoporosis Photosensitivity Rash (Stevens-Johnson syndrome) SLE-like syndrome Teeth discoloration Tendonitis, tendon rupture, cartilage damage
Neurologic
Cinchonism
Parkinson-like syndrome
Seizures
Tardive dyskinesia
Renal/Genitourinary
Diabetes insipidus Fanconi syndrome Hemorrhagic cystitis Intersitital nephritis SIDADH
Respiratory
Dry cough
Pulmonary fibrosis
Multiorgan
Antimuscarinic
Disulfiram-like reaction
Nephrotoxicity/ototoxicity
Cytochrome P450 inducers (+)
9
Chronic alcohol use Modafinil St. John's wort Phenytoin Phenobarbital Nevapine Rifampin Griseofulvin Carbamazepine
Cytochrome P450 substrates
8
Anti-epileptics Antidepressants Antipsychotics Anesthetics Theophylline Warfarin Statins OCPs
Cytochrome P450 inhibitors (-)
12
Acute alcohol abuse Gemfibrozil Ciprofloxacin Isoniazid Grapefruit juice Quinidine Amiodarone Ketoconazole Macrolides Sulfonamides Cimetidine Ritonavir
Sulfa drugs
“Popular FACTSSS”
Probenecid Furosemide Acetazolamide Celecoxib Thiazides Sulfonamide antibiotics Sulfasalazine Sulfonylureas "Popular FACTSSS"
Potential reactions associated with sulfa allergy
Fever, UTI, Stevens-Johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria (hives)
Symptoms range from mild to life threatening
Coronary vasospasm
Cocaine
Sumatriptan
Ergot alkaloids
Cutaneous flushing
“VANC”
Vancomycin
Adenosine
Niacin
CCBs
Dilated cardiomyopathy
Doxorubicin
Danorubicin
Torsades de pointes
Class III (amiodarone, ibutilide, dofetilide, sotalol) and Class IA (quinidine, procainamide, disopyramide) antiarrhythmics
Macrolide antibiotics
Antipsychotics
TCAs
Prolonged QT interval
Adrenocortical insufficiency
HPA suppression secondary to glucocorticoid withdrawal
Hot flashes
Tamoxifen
Clomiphene
Hyperglycemia
“Taking Pills Necessitates Having Blood Checked”
Tacrolimus Protease inhibitors Niacin HCTZ B-blockers Corticosteroids
Hypothyroidism
Lithium
Amiodarone
Sulfonamides
Acute cholestatic hepatitis, jaundice
Erythromycin
Diarrhea
“Might Excite Colon On Accident”
Metformin Erythromycin Colchicine Orlistat Acarbose
Focal to massive hepatic necrosis
“Liver HAVAc”
Halothane
Amanita phalloides (death cap mushroom)
Valproic acid
Acetaminophen
Hepatitis
Isoniazid
Pancreatitis
“Drugs Causing A Violent Abdominal Distress”
Didanosine Corticosteroids Alcohol Valproic acid Azathioprine Diuretics (furosemide, HCTZ)
Pseudomembranous colitis
Clindamycin
Ampicillin
Cephalosporins
Antibiotics predispose to superinfection by resistant C. difficile
Agranulocytosis
“Drugs CCCrush Myeloblasts and Promyelocytes”
Dapsone Clozapine Carbamazepine Colchicine Methimazole Propylthiouracil
Aplastic anemia
“Can’t Make New Blood Cells Properly”
Carbamazepine Methimazole NSAIDs Benzene Chloramphenicol Propylthiouracil
Direct Coombs-positive hemolytic anemia
Methyldopa
Penicillin
Gray baby syndrome
Chloramphenicol
Hemolysis in G6PD deficiency
“Hemolysis IS D PAIN”
Isoniazid Sulfonamides Dapsone Primaquine Aspirin Ibuprofen Nitrofurantoin
Megalobastic anemia
“Having a megaloblast with PMS”
Phenytoin
Methotrexate
Sulfa drugs
Thrombocytopenia
Heparin
Cimetidine
Thrombotic complications
OCPs (estrogens)
Fat redistribution
“Fat PiG”
Protease inhibitors
Glucocorticoids
Gingival hyperplasia
Phenytoin
Verapamil
Cyclosporine
Nifedipine
Hyperuricemia (gout)
“Painful Tophi and Feet Need Care”
Pyrazinamide Thiazides Furosemide Niacin Cyclosporine
Myopathy
Fibrates Niacin Colchicine Hydroxychloroquine IFN-a Penicillamine Statins Glucocorticoids
Osteoporosis
Corticosteroids
Heparin
Photosensitivity
“SAT For Photo”
Sulfonamides
Amiodarone
Tetracyclines
5-FU
Rash (Stevens-Johnson syndrome)
“Steven Johnson has epileptic Allergy to Sulfa drugs and PCN”
Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital)
Allopurinol
Sulfa drugs
Penicillin
SLE-like syndrome
“Having lupus is SHIPP-E”
Sulfa drugs Hydralazine INH Procainamide Phenytoin Etanercept
Teeth discoloration
Tetracyclines
Tendonitis, tendon rupture, cartilage damage
Fluoroquinolones
Cinchonism
Quinidine
Quinine
Parkinson-like syndrome
“Cogwheel rigidity of ARM”
Antipsychotics
Reserpine
Metoclopramide
Seizures
“With seizures, I BITE My tongue
INH (vitamin B6 deficiency) Bupropion Imipenem/cilastatin Tramadol Enflurane Metoclopramide
Tardive dyskinesia
Antipsychotics
Metoclopramide
Diabetes insipidus
Lithium
Demeclocycline
Fanconi syndrome
Expired tetracycline
Hemorrhagic cystitis
Cyclophosphamide
Ifosfamide
Prevent with mesna
Interstitial nephritis
Methicillin
NSAIDs
Furosemide
SIADH
“Can’t Concentrate Serum Sodium”
Carbamazepine
Cyclophosphamide
SSRIs
Dry cough
ACE inhibitors
Pulmonary fibrosis
“Breathing Air Badly from Medications”
Bleomycin
Amiodarone
Busulfan
Methotrexate
Antimuscarinic
Atropine
TCAs
H1-blockers
Antipsychotics
Disulfiram-like reaction
Metronidazole Certain cephalosporins Griseofulvin Procarbazine 1st generation sulfonylureas (Tolbutamide, Chlorpropamide)
Nephrotoxicity/Ototoxicity
Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin