Drug reactions Flashcards
Adrenocortical insufficiency
HPA suppression secondary to glucocorticoid withdrawal
Hot flashes
- Tamoxifen
- Clomiphene
Hyperglycemia
- Tacrolimus
- Protease inhibitors
- Niacin
- HCTZ
- Corticosteroids
“Taking Pills Necessitates Having blood Checked”
Hypothyroidism
- Lithium
- Amiodarone
- Sulfonamides
Acute cholestatic hepatitis, jaundice
Erythromycin
Diarrhea
- Acamprosate
- Acarbose
- Cholinesterase inhibitors
- Colchicine
- Erythromycin
- Ezetimibe
- Metformin
- Misoprostol
- Orlistat
- Pramlintide
- Quinidine
- SSRIs
Focal to massive hepatic necrosis
- Halothane
- Amanita phalloides (death cap mushroom)
- Valproic acid
- Acetaminophen
Liver “HAVAc”
Hepatitis
- Rifampin
- Isoniazid
- Pyrazinamide
- Statins
- Fibrates
Pancreatitis
- Didanosine
- Corticosteroids
- Alcohol
- Valproic acid
- Azathioprine
- Diuretics (furosemide, HCTZ
“Drugs Causing A Violent Abdominal Distress”
Pill-induced esophagitis
- Tetracyclines
- Bisphosphonates
- Potassium chloride
Caustic effect minimized with upright posture and adequate water ingestion
Pseudomembrarnous colitis
- Clindamycin
- Ampicillin
- Cephalosporins
Antibiotics predispose to superinfection by resistant C difficile
Agranulocytosis
- Clozapine
- Carbamazepine
- Propylthiouracil
- Methicmazole
- Colchicine
- Ganciclovir
“Can Cause Pretty Major Collapse of Granulocytes”
Aplastic anemia
- Carbamazepine
- Methimazole
- NSAIDs
- Benzene
- Chloramphenicol
- Propylthiouracil
“Can’t Make New Blood Cells Properly”
Direct Coombs-positive hemolytic anemia
- Methyldopa
- Penicillin
Gray baby syndrome
Chloramphenicol
Hemolysis in G6PD deficiency
- Isoniazid
- Sulfonamides
- Dapsone
- Primaquine
- Aspirin
- Ibuprofen
- Nitrofurantoin
“Hemolysis IS D PAIN”
Megaloblastic anemia
- Phenytoin
- Methotrexate
- Sulfa drugs
“Having a BLAST with PMS”
Thrombocytopenia
Heparin
Thrombotic complications
- OCPs
- Hormone replacement therapy
Fat redistribution
- Protease inhibitors
- Glucocorticoids
“Fat PiG”
Gingival hyperplasia
- Phenytoin
- Ca2+ channel blockers
- Cyclosporine
“Painful Tophi and Feet Need Care”
Hyperuricemia (gout)
- Pyrizinamide
- Thiazides
- Furosemides
- Niacin
- Cyclosporine
Myopathy
- Fibrates
- Niacin
- Colchicine
- Hydroxychloroquine
- Interferon alpha
- Penicillamine
- Statins
- Glucocorticoids
Osteoporosis
- Glucocorticoids
- Heparin
Photosensitivity
- Sulfonamides
- Amiodarone
- Tetracyclines
- 5-FU
“SAT For Photo”
Rash (SJS)
- Anti-epileptic drugs (especially lamotrigine)
- Allopurinol
- Sulfa drugs
- Penicillin
“Steven Johnson has epileptic allergy to sulfa drugs and penicillin”
SLE-like syndrome
- Sulfa drugs
- Hydralazine
- Isoniazid
- Procainamide
- Phenytoin
- Etanercept
Having lupus is “SHIPP-E”
Teeth discoloration
Tetracyclines
Tendonitis, tendon rupture and cartilage damage
Fluroquinolones
Cinchonism
- Quinidine
- Quinine
Parkinson-like syndrome
- Anti-psychotics
- Reserpine
- Metoclopramide
“Cogwheel rigidity of ARM”
Seizures
- Isoniazid (vitamin B6 deficiency)
- Bupropion
- Imipenem/cilastatin
- Tramadol
- Enflurane
“With seizures, I BITE my tongue”
Tardive dyskinesia
- Anti-psychotics
- Metoclopramide
Diabetes insipidus
- Lithium
- Demeclocycline
Fanconi syndrome
- Tenofovir
- Isofosfamide
Hemorrhagic cystitis
- Cyclophosphamide
- Isofosfamide
Interstitial nephritis
- Methicillin
- NSAIDs
- Furosemide
SIADH
- Carbamazepine
- Cyclophosphamide
- SSRIs
“Can’t Concentrate Serum Sodium”
Dry cough
ACE inhibitors
Pulmonary fibrosis
- Methotrexate
- Nitrofurantoin
- Carmustine
- Bleomycin
- Busulfan
- Amiodarone
“My Nose Cannot Breathe Bad Air”
Antimuscarinic
- Atropine
- TCAs
- H1 blockers
- Anti-psychotics
Disulfiram-like reaction
- Metronidazole
- Certain cephalosporins
- Griseofulvin
- Procarbaine
- 1st generation sulfonylureas
Nephrotoxicity/ ototoxicity
- Aminoglycosides
- Vancomycin
- Loop diuretics
- Cisplatin
- Cisplatin toxicity may respond to amifostine
Coronary vasospasm
- Cocaine
- Sumitriptan
- Ergot alkaloids
Cutaneous flushing
- Vancomycin
- Adenosine
- Niacin
- Ca2+ channel blockers
- Enchinocandins
“VANCE”
Dilated cardiomyopathy
- Anthracyclines (eg doxorubicin, daunorubicin)
- Prevent with dexrazoxane
Torsades de pointes
- AntiArrhythmics (class IA, III)
- AntiBiotics (eg macrolides)
- Anti”C”ychotics (eg haloperidol)
- AntiDepressants (eg TCAs)
- AntiEmetics (eg ondansetron)
“ABCDE”
