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Step 1 > Drug reactions > Flashcards

Drug reactions Flashcards

1
Q

Adrenocortical insufficiency

A

HPA suppression secondary to glucocorticoid withdrawal

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2
Q

Hot flashes

A
  • Tamoxifen

- Clomiphene

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3
Q

Hyperglycemia

A
  • Tacrolimus
  • Protease inhibitors
  • Niacin
  • HCTZ
  • Corticosteroids

“Taking Pills Necessitates Having blood Checked”

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4
Q

Hypothyroidism

A
  • Lithium
  • Amiodarone
  • Sulfonamides
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5
Q

Acute cholestatic hepatitis, jaundice

A

Erythromycin

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6
Q

Diarrhea

A
  • Acamprosate
  • Acarbose
  • Cholinesterase inhibitors
  • Colchicine
  • Erythromycin
  • Ezetimibe
  • Metformin
  • Misoprostol
  • Orlistat
  • Pramlintide
  • Quinidine
  • SSRIs
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7
Q

Focal to massive hepatic necrosis

A
  • Halothane
  • Amanita phalloides (death cap mushroom)
  • Valproic acid
  • Acetaminophen

Liver “HAVAc”

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8
Q

Hepatitis

A
  • Rifampin
  • Isoniazid
  • Pyrazinamide
  • Statins
  • Fibrates
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9
Q

Pancreatitis

A
  • Didanosine
  • Corticosteroids
  • Alcohol
  • Valproic acid
  • Azathioprine
  • Diuretics (furosemide, HCTZ

“Drugs Causing A Violent Abdominal Distress”

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10
Q

Pill-induced esophagitis

A
  • Tetracyclines
  • Bisphosphonates
  • Potassium chloride

Caustic effect minimized with upright posture and adequate water ingestion

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11
Q

Pseudomembrarnous colitis

A
  • Clindamycin
  • Ampicillin
  • Cephalosporins

Antibiotics predispose to superinfection by resistant C difficile

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12
Q

Agranulocytosis

A
  • Clozapine
  • Carbamazepine
  • Propylthiouracil
  • Methicmazole
  • Colchicine
  • Ganciclovir

“Can Cause Pretty Major Collapse of Granulocytes”

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13
Q

Aplastic anemia

A
  • Carbamazepine
  • Methimazole
  • NSAIDs
  • Benzene
  • Chloramphenicol
  • Propylthiouracil

“Can’t Make New Blood Cells Properly”

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14
Q

Direct Coombs-positive hemolytic anemia

A
  • Methyldopa

- Penicillin

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15
Q

Gray baby syndrome

A

Chloramphenicol

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16
Q

Hemolysis in G6PD deficiency

A
  • Isoniazid
  • Sulfonamides
  • Dapsone
  • Primaquine
  • Aspirin
  • Ibuprofen
  • Nitrofurantoin

“Hemolysis IS D PAIN”

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17
Q

Megaloblastic anemia

A
  • Phenytoin
  • Methotrexate
  • Sulfa drugs

“Having a BLAST with PMS”

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18
Q

Thrombocytopenia

A

Heparin

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19
Q

Thrombotic complications

A
  • OCPs

- Hormone replacement therapy

20
Q

Fat redistribution

A
  • Protease inhibitors
  • Glucocorticoids

“Fat PiG”

21
Q

Gingival hyperplasia

A
  • Phenytoin
  • Ca2+ channel blockers
  • Cyclosporine

“Painful Tophi and Feet Need Care”

22
Q

Hyperuricemia (gout)

A
  • Pyrizinamide
  • Thiazides
  • Furosemides
  • Niacin
  • Cyclosporine
23
Q

Myopathy

A
  • Fibrates
  • Niacin
  • Colchicine
  • Hydroxychloroquine
  • Interferon alpha
  • Penicillamine
  • Statins
  • Glucocorticoids
24
Q

Osteoporosis

A
  • Glucocorticoids

- Heparin

25
Q

Photosensitivity

A
  • Sulfonamides
  • Amiodarone
  • Tetracyclines
  • 5-FU

“SAT For Photo”

26
Q

Rash (SJS)

A
  • Anti-epileptic drugs (especially lamotrigine)
  • Allopurinol
  • Sulfa drugs
  • Penicillin

“Steven Johnson has epileptic allergy to sulfa drugs and penicillin”

27
Q

SLE-like syndrome

A
  • Sulfa drugs
  • Hydralazine
  • Isoniazid
  • Procainamide
  • Phenytoin
  • Etanercept

Having lupus is “SHIPP-E”

28
Q

Teeth discoloration

A

Tetracyclines

29
Q

Tendonitis, tendon rupture and cartilage damage

A

Fluroquinolones

30
Q

Cinchonism

A
  • Quinidine

- Quinine

31
Q

Parkinson-like syndrome

A
  • Anti-psychotics
  • Reserpine
  • Metoclopramide

“Cogwheel rigidity of ARM”

32
Q

Seizures

A
  • Isoniazid (vitamin B6 deficiency)
  • Bupropion
  • Imipenem/cilastatin
  • Tramadol
  • Enflurane

“With seizures, I BITE my tongue”

33
Q

Tardive dyskinesia

A
  • Anti-psychotics

- Metoclopramide

34
Q

Diabetes insipidus

A
  • Lithium

- Demeclocycline

35
Q

Fanconi syndrome

A
  • Tenofovir

- Isofosfamide

36
Q

Hemorrhagic cystitis

A
  • Cyclophosphamide

- Isofosfamide

37
Q

Interstitial nephritis

A
  • Methicillin
  • NSAIDs
  • Furosemide
38
Q

SIADH

A
  • Carbamazepine
  • Cyclophosphamide
  • SSRIs

“Can’t Concentrate Serum Sodium”

39
Q

Dry cough

A

ACE inhibitors

40
Q

Pulmonary fibrosis

A
  • Methotrexate
  • Nitrofurantoin
  • Carmustine
  • Bleomycin
  • Busulfan
  • Amiodarone

“My Nose Cannot Breathe Bad Air”

41
Q

Antimuscarinic

A
  • Atropine
  • TCAs
  • H1 blockers
  • Anti-psychotics
42
Q

Disulfiram-like reaction

A
  • Metronidazole
  • Certain cephalosporins
  • Griseofulvin
  • Procarbaine
  • 1st generation sulfonylureas
43
Q

Nephrotoxicity/ ototoxicity

A
  • Aminoglycosides
  • Vancomycin
  • Loop diuretics
  • Cisplatin
  • Cisplatin toxicity may respond to amifostine
44
Q

Coronary vasospasm

A
  • Cocaine
  • Sumitriptan
  • Ergot alkaloids
45
Q

Cutaneous flushing

A
  • Vancomycin
  • Adenosine
  • Niacin
  • Ca2+ channel blockers
  • Enchinocandins

“VANCE”

46
Q

Dilated cardiomyopathy

A
  • Anthracyclines (eg doxorubicin, daunorubicin)

- Prevent with dexrazoxane

47
Q

Torsades de pointes

A
  • AntiArrhythmics (class IA, III)
  • AntiBiotics (eg macrolides)
  • Anti”C”ychotics (eg haloperidol)
  • AntiDepressants (eg TCAs)
  • AntiEmetics (eg ondansetron)

“ABCDE”

Step 1 (25 decks)

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