Drug reactions 0423FA

Question 1

cardio: coronary vasospasm

Answer 1

cocaine.

sumatriptan.

Question 2

cardio: cutaneous flushing

Answer 2

Vancomycin.
Adenosine.
Niacin.
CCB.

“VANC”

Question 3

cardio: dilated cardiomyopathy

Answer 3

doxorubicin (adriamycin).

daunorubicin.

Question 4

cardio: torsades de pointes

Answer 4

class III (sotolol) and 
class IA (quinidine) antiarrhythmics.

Question 5

hematologic: agranulocytosis

Answer 5

Clozapine. 
Carbamazepine.
Colchicine.
Propylthiouracil.
Methimazole.
Dapsone.

“Agranulocytosis Can Certainly Cause Pretty Major Damage”

Question 6

hematologic: aplastic anemia

Answer 6

chloramphenicol.
benzene.
NSAIDs.
propylthiouracil.
methimazole.

Question 7

hematologic: direct Coombs positive hemolytic anemia

Answer 7

methyldopa

Question 8

hematologic: gray baby syndrome

Answer 8

chloramphenicol

Question 9

hematologic: hemolysis in G6PD-deficient pts

Answer 9

Isoniazid.
Sulfonamides.
Primaquine.
Aspirin.
Ibuprofen.
Nitrofurantoin.

“hemolysis IS PAIN”

Question 10

hematologic: megaloblastic anemia

Answer 10

Phenytoin.
Methotrexate.
Sulfa drugs.

“having a blast with PMS”

Question 11

hematologic: thrombotic complications

Answer 11

OCPs (estrogen, progestin)

Question 12

resp: cough

Answer 12

ACE inhibitors

Question 13

resp: pulmonary fibrosis

Answer 13

BLeomycin.
Amiodarone.
Busulfan.

“it’s hard to BLAB when you have pulmo fibrosis”

Question 14

GI: acute cholestatic hepatitis

Answer 14

erythromycin

Question 15

GI: focal to massive hepatic necrosis

Answer 15

Halothane.
Acetaminophen.
Valproic acid.
Amanita phalloides.

“liver HAVAc”

Question 16

GI: hepatitis

Answer 16

isoniazid (INH)

Question 17

GI: pseudomembranous colitis

Answer 17

clindamycin, ampicillin

Question 18

endo/repro: adrenocortical insuff

Answer 18

glucocorticoid withdrawal - due to HPA suppression

Question 19

endo/repro: gynecomastia

Answer 19

Spironolactone.
Digitalis.
Cimetidine.
Estrogens.
chronic Alcohol.
Ketoconazole.

“Some Drugs Create Extremely Awesome Knockers”

Question 20

endo/repro: hot flashes

Answer 20

tamoxifen, clomiphene

Question 21

endo/repro: hypothyroidism

Answer 21

lithium.
amiodarone.
sulfonamides.

Question 22

endo/repro: hyperglycemia

Answer 22

niacin.
tacrolimus.
protease inhibitors.

Question 23

MSS/CT: fat redistribution

Answer 23

glucocorticoids.

protease inhibitors.

Question 24

MSS/CT: gingival hyperplasia

Answer 24

phenytoin.

verapamil.

Question 25

MSS/CT: gout

Answer 25

``` furosemide. thiazides. niacin. cyclosporine. pyrazinamide. ```

Question 26

MSS/CT: myopathies

Answer 26

``` Fibrates. Niacin. Colchicine. Hydroxychloroquine. Interferon alpha. Penicillamine. Statins. Glucocorticoids. ``` "Fish N CHIPS Gives you myopathies"

Question 27

MSS/CT: osteoporosis

Answer 27

corticosteroids. | heparin.

Question 28

MSS/CT: photosensitivity

Answer 28

Sulfonamides. Amiodarone. Tetracycline. "SAT for a photo"

Question 29

MSS/CT: rash (SJS)

Answer 29

``` Penicillin. Ethosuxamide. Carbamazepine. Sulfa drugs. Lamotrigine. Allopurinol. Phenytoin. Phenobarbital. ``` "bad rash after PEC SLAPP"

Question 30

MSS/CT: SLE-like syndrome

Answer 30

Hydralazine. INH. Procainamide. Phenytoin. "it's not HIPP to have lupus"

Question 31

MSS/CT: tendonitis, tendon rupture, cartilage damage (kids)

Answer 31

fluoroquinolones

Question 32

renal/GU: diabetes insipidus

Answer 32

lithium. | demeclocycline.

Question 33

renal/GU: Fanconi syndrome

Answer 33

expired tetracycline

Question 34

renal/GU: interstitial nephritis

Answer 34

methicillin. NSAIDs. furosemide.

Question 35

renal/GU: hemorrhagic cystitis

Answer 35

cyclophosphamide. ifosfamide. *prevent by coadmin with mesna

Question 36

renal/GU: SIADH

Answer 36

carbamazepine. | cyclophosphamide.

Question 37

neuro: cinchonism

Answer 37

quinidine. | quinine.

Question 38

neuro: parkinson like syndrome

Answer 38

antipsychotics. reserpine. metoclopramide.

Question 39

neuro: seizures

Answer 39

bupropion. imipenem/cilastatin. INH.

Question 40

neuro: tardive dyskinesia

Answer 40

antipsychotics

Question 41

multiorgan: antimuscarinic

Answer 41

atropine. TCAs. H1 blockers. neuroleptics.

Question 42

multiorgan: disulfiram-like reaction

Answer 42

metronidazole. certain cephalosporins. procarbazine. 1G sulfonylureas.

Question 43

multiorgan: nephrotoxicity + ototoxicity

Answer 43

aminoglycosides. vancomycin. loop diuretics. cisplatin.