Drug of Choice, AEDs Flashcards
1
Q
What drugs are indicated as monotherapy for partial seizures?
A
FDA indication
- Carbamazepine
- Oxcarbazepine
- Phenytoin
- Topiramate
Similar effectiveness, fewer side effects
- Lamotrigine
- Levetiracetam
2
Q
What drugs are indicated as monotherapy for Generalized-Onset Tonic-Clonic Seizures?
A
FDA:
- Valproate
- Topiramate
Others shown to be effective:
- Zonisamide
- Levetiracetam
- Phenytoin, Carbamazepine (may exacerbate absence and myoclonic sz )
- Lamotrigine (may exacerbate myoclonic sz of symptomatic generalized epilepsies)
3
Q
What drugs are indicated as monotherapy for Absence Seizures?
A
- Ethosuximide (limited spectrum, absence only)
- Valproate
Also shown to be effective:
- Lamotrigine
Second-line:
- Zonisamide, Levetiracetam, Topiramate, Felbamate, Clonazepam
4
Q
What drugs are indicated as monotherapy for Myoclonic seizures?
A
- Valproate
- Clonazepam (FDA indication)
- Levetiracetam (FDA indication as adjunctive)
5
Q
What drugs are indicated as monotherapy for Lennox-Gastaut Syndrome?
A
Monotherapy: PVC
- Clonazepam
- Valproate
- Phenytoin
Adjunctive Treatment:
- lamotrigine
- topiramate
- felbamate
- rufinamide
- clobazam
6
Q
What is the first choice drug in treating Status Epilepticus?
A
Benzodiazepines: Diazepam/ Lorazepam
Phenytoin given after to increase half life
7
Q
What is the second choice drug in treating Status Epilepticus?
A
Phenobarbital
8
Q
A
